Antitumor Constituents from Formosan Marine Sponge Dysidea avara
碩士 === 國立中山大學 === 海洋資源學系研究所 === 88 === 英文摘要 The marine sponge Dysidea avara was collected along south seashore area of Kenting. Fractionation of the EtOH extract by using silica gel column chromatografphy and HPLC yielded avarol(1) and avarone(2). The structure elucidation of 1 and 2 was achieved b...
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ndltd-TW-088NSYS52770092016-07-08T04:22:57Z http://ndltd.ncl.edu.tw/handle/41845857833512180924 Antitumor Constituents from Formosan Marine Sponge Dysidea avara 台灣產海綿Dysideaavara抗癌及相關活性成分之研究 Hau-Ching Liu 呂清豪 碩士 國立中山大學 海洋資源學系研究所 88 英文摘要 The marine sponge Dysidea avara was collected along south seashore area of Kenting. Fractionation of the EtOH extract by using silica gel column chromatografphy and HPLC yielded avarol(1) and avarone(2). The structure elucidation of 1 and 2 was achieved by NMR(300 MHz), EIMS, FABMS, UV, IR and specific rotation. In order to study the structure and activity relationship, compound 1 was acylated to yield a series of avarol derivaties(14 ~ 20). In addition, three compounds(22 ~ 24) were prepared from methylhydroxyquinone via acylation. Derivatives 14 ~ 20 and 22 ~ 24 were confirmed by spectral methods including NMR, MS, UV and IR as 2’,5’-O -dibenzoylavarol(14)、2’,5’-O-〔p-chlorobenzoyl〕avarol(15)、2’,5’-O-dicinnamoyl -avarol(16)、2’,5’-O-〔p-bromobenzoyl〕avarol(17)、2’,5’-O -dioctanoylavarol(18)、2’,5’-O-〔p-florobenzoyl〕avarol(19)、Diacetylavarol(20)、methylhydroxyquinone(22)、2’,5’-O-〔p-chlorobenzoyl〕methylhydroxyquinone(23)、diacetylmethylhydroxyquinone(24). All of these compounds were send to National Health Research Institute and National Research Institute of Chinese Medicine for antitumor and antiviral tests in vitro. The investigation of their structure and activity relationship is now in progress. none 沈雅敬 2000 學位論文 ; thesis 81 zh-TW |
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碩士 === 國立中山大學 === 海洋資源學系研究所 === 88 === 英文摘要
The marine sponge Dysidea avara was collected along south seashore area of Kenting. Fractionation of the EtOH extract by using silica gel column chromatografphy and HPLC yielded avarol(1) and avarone(2). The structure elucidation of 1 and 2 was achieved by NMR(300 MHz), EIMS, FABMS, UV, IR and specific rotation. In order to study the structure and activity relationship, compound 1 was acylated to yield a series of avarol derivaties(14 ~ 20). In addition, three compounds(22 ~ 24) were prepared from methylhydroxyquinone via acylation. Derivatives 14 ~ 20 and 22 ~ 24 were confirmed by spectral methods including NMR, MS, UV and IR as 2’,5’-O -dibenzoylavarol(14)、2’,5’-O-〔p-chlorobenzoyl〕avarol(15)、2’,5’-O-dicinnamoyl -avarol(16)、2’,5’-O-〔p-bromobenzoyl〕avarol(17)、2’,5’-O -dioctanoylavarol(18)、2’,5’-O-〔p-florobenzoyl〕avarol(19)、Diacetylavarol(20)、methylhydroxyquinone(22)、2’,5’-O-〔p-chlorobenzoyl〕methylhydroxyquinone(23)、diacetylmethylhydroxyquinone(24). All of these compounds were send to National Health Research Institute and National Research Institute of Chinese Medicine for antitumor and antiviral tests in vitro. The investigation of their structure and activity relationship is now in progress.
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none Hau-Ching Liu 呂清豪 |
author |
Hau-Ching Liu 呂清豪 |
spellingShingle |
Hau-Ching Liu 呂清豪 Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
author_sort |
Hau-Ching Liu |
title |
Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
title_short |
Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
title_full |
Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
title_fullStr |
Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
title_full_unstemmed |
Antitumor Constituents from Formosan Marine Sponge Dysidea avara |
title_sort |
antitumor constituents from formosan marine sponge dysidea avara |
publishDate |
2000 |
url |
http://ndltd.ncl.edu.tw/handle/41845857833512180924 |
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