Outcome Evaluation of Different Modes of Nutrition Supply within the First forty-eight Hours in Preterm Neonates

• Main Authors: Yu-Hsuan Yen, 顏瑜萱
• Other Authors: Feng-Lin Hsu
• Format: Others
• Language: en_US
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/90366167209632816880

碩士 === 台北醫學院 === 藥學研究所 === 88 === In this retrospective study, we evaluated outcomes of different modes of nutrition supplementation in preterm neonates. Clinical outcomes of 9 infants in the early nutrition (EN) group, whom were given early peripheral parenteral amino acids and minimal hypocaloric enteral feeding within the first 48 hours, were compared with that of 6 infants in the delayed nutrition (DN) group, whom were given nutrition 48 hours after birth. The two groups were similar with respect to gestational age, birth weight, and perinatal diagnosis. In EN group, the days of reaching full enteral feeding were shorter than that in DN group (12.4±6.0 days vs. 22.6±6.6 days, p < 0.01). The days of nothing by mouth (NPO) in EN and DN infants were 0.7±0.5 days and 5.2±4.3 days, respectively (p < 0.05). The age of maximal weight loss of EN and DN infants were 4.8±1.6 days and 7.5±2.2 days, respectively (p < 0.05). Even though the duration of parenteral nutrition, the time used assisted ventilation, birth weight regain, the percentage of maximal weight loss, weight gain after day 10 and length of hospitalization did not show statistical significance between the two groups, there is a trend forward better outcome in the EN group. Therefore, early peripheral parenteral amino acids in combination with minimal hypocaloric enteral feeding can facilitate early positive energy balance. The same 9 infants in the EN group were also compared with other 15 infants, whom did not receive parenteral nutrition (NPN). The two groups were both given enteral feeding within the first 48 hours. Average gestation age of the EN group was statistically less than that of NPN group. (31.2±1.9 weeks vs. 32.5±0.8 weeks, p < 0.05) Average birth weight of EN group was lower than that of NPN group. (1428±267 g vs. 1710±229 g, p < 0.05) The severity of perinatal diagnosis of EN group was more advanced than that of NPN group. There were no significant differences in the age of reaching full enteral feeding, the days of NPO, and the age of birth weight regain. The age of maximal weight loss in the EN and NPN group were 4.8±1.6 days and 6.6±2.1 days, respectively (p < 0.05). Therefore, early peripheral parenteral amino acids can shorter the period of weight loss after birth. This study demonstrated several beneficial effects of early peripheral parenteral amino acids in combination with minimal hypocaloric enteral feeding. This mode of nutrition supplementation can facilitate full enteral feeding sooner, achieve of positive nitrogen and energy balance ealier, and fasten birth weight regain.