Investigation the co-existence of oral mucosal disease associate with betel quit chewing, smoking and drinking

• Main Author: 謝順得
• Other Authors: 謝天渝
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/78413205729185759622

碩士 === 高雄醫學大學 === 口腔衛生科學研究所 === 89 === The association of betel quid chewing with oral cancer and oral mucosal disease has been verified in many studies. Most of these study results were discussed on a single-disease base. In practice, one can usually find several different diseases coexist in one patient at the same time. The association between coexistence of oral mussel diseases and betel quid chewing, smoking and drinking has not been thoroughly investigated. This study reviewed 393 patients with oral mucosal diseases at the Oral and Maxillofacial Surgery Department of Kaohsiung Medical University Hospital. The target oral mucosal diseases included 11 main lesions. For example: squamous cell carcinoma (SCC), oral submucous fibrosis (OSF), hyperkeratosis, epithelial hyperplasia, epithelial dysplasia, verrucous hyperplasia, verrucous carcinoma, lichen planus and carcinoma in situ. Our investigation identified that 37.7% of patients had coexistent mucosal diseases: There were also 48.4% of SCC patients had coexistent mucosal diseases, and 29.9% of squamous cell carcinoma patients had coexistence with epithelial dysplasia. There were 27.2% of SCC patients had coexistence with OSF, and 25.5% of SCC patients had coexistence with epithelial hyperplasia. There were 22.8% of SCC patients coexistent with hyperkeratosis, 18.5% of SCC patients coexistent with verrucous hyperplasia, and 10.3% of SCC patients coexistent with verrucous carcinoma. There were 50.3% of OSF patients coexistent with hyperkeratosis, 34.5% of OSF patients coexistent with squamous cell carcinoma, and 13.1% of OSF patients coexistent with verrucous carcinoma. All of the lichen planus patients also suffered from SCC had betel quid chewing, smoking and drinking habits. The cluster analysis was used to group the 393 patients into different disease patterns according the 11-target oral musosal diseases. There were 10 disease patterns summarized by the analysis results. In the group 1, most of patients were squamous cell carcinoma only. Majority of oral submucous fibrosis were found to also have hyperkeratosis, epithelial hyperplasia, epithelial dysplasia, hyperkeratosis, and squamous cell carcinoma. There were 44.5% of SCC patients have habits of betel quid chewing, smoking and drinking in stage Ⅲ and Ⅳ. Comparing our results with previous studies in the same department, it was found that age of diagnosed with SCC had become younger in the recent 20 years, and there are more and more patients with stage Ⅲ and Ⅳ.