Total synthesis of Kaempferol and Kaempferol derivatives, and DDO reactions
碩士 === 國立彰化師範大學 === 科學教育研究所 === 89 === Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2001
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| Online Access: | http://ndltd.ncl.edu.tw/handle/67811047162892410525 |
| Summary: | 碩士 === 國立彰化師範大學 === 科學教育研究所 === 89 === Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I2 oxidative-promoting-cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.
Hydroxylation and chlorination of flavones and aromatic compounds with DDO are described. The natural quercetogetin 44and ladanein 24 were synthesized via this methodology. Flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the adjacent C-6 carbon atom by DDO.
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