Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway
碩士 === 國立中山大學 === 生物科學系研究所 === 89 === Vagal sensory afferent innervation corresponds to regulation of neurogenic inflammation in the airways. Capsaicin is mostly used for stimulation of sensory nerves that induce pain and inflammatory responses. It can specifically stimulate sensory afferent nerve...
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ndltd-TW-089NSYS51120122016-01-29T04:33:30Z http://ndltd.ncl.edu.tw/handle/04183134486489386718 Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway 胸迷走神經分支於大鼠下呼吸道之神經性血漿滲漏調節之角色 Yi-Chung Lee 李宜忠 碩士 國立中山大學 生物科學系研究所 89 Vagal sensory afferent innervation corresponds to regulation of neurogenic inflammation in the airways. Capsaicin is mostly used for stimulation of sensory nerves that induce pain and inflammatory responses. It can specifically stimulate sensory afferent nerves, inducing neurogenic inflammation in the airways. According the past studies, we have found the right thoracic vagus nerve (RTVN) and right recurrent laryngeal nerve (RRLN); branches of right thoracic vagus trunk (RTVT) mediate different degree of neurogenic inflammation by intraenous injection of capsaicin (300 nmol/ml/kg). In order to investigate the innervation from the RTVN and RRLN of rat tracheobronchi and their involvement in plasma exudation, we injected 3 μl of capsaicin (10 mg/ml) into RTVT and denervated the RRLN or RTVN and used India ink as tracer dye to label the leaky microvessels. Our observation indicated that injection of capsaicin into the RTVT coud induce obvious plasma exudation in trachea (area density of leaky blood vessels was about 22%), but plasma exudation was significantly decreased after denervation of RRLN. The left upper side of trachea was decreased by 77.6% and the right upper side decreased by 84.5%. This phenomenon was not caused by denervation of RTVN. The results suggest that vagal nerve innervation of upper trachea mostly came from the RLN. Otherwise, capsaicin injection into the RTVT also induced neurogenic inflammation in the larynx. Experimental denervation of both superior and recurrent laryngeal nerves resulted in a decrease of plasma extravasation by 84.98%. Denervation of either RTVN or RRLN also decreased the plasma extravasation in the larynx. The evidence suggest that sensory fibers in the superior laryngeal nerve, recurrent laryngeal nerve, and thoracic vagus nerve might come from the same population of vagal ganglion sensory neurons. Hung-tu Huang 黃宏圖 2001 學位論文 ; thesis 48 zh-TW |
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碩士 === 國立中山大學 === 生物科學系研究所 === 89 === Vagal sensory afferent innervation corresponds to regulation of neurogenic inflammation in the airways. Capsaicin is mostly used for stimulation of sensory nerves that induce pain and inflammatory responses. It can specifically stimulate sensory afferent nerves, inducing neurogenic inflammation in the airways. According the past studies, we have found the right thoracic vagus nerve (RTVN) and right recurrent laryngeal nerve (RRLN); branches of right thoracic vagus trunk (RTVT) mediate different degree of neurogenic inflammation by intraenous injection of capsaicin (300 nmol/ml/kg). In order to investigate the innervation from the RTVN and RRLN of rat tracheobronchi and their involvement in plasma exudation, we injected 3 μl of capsaicin (10 mg/ml) into RTVT and denervated the RRLN or RTVN and used India ink as tracer dye to label the leaky microvessels. Our observation indicated that injection of capsaicin into the RTVT coud induce obvious plasma exudation in trachea (area density of leaky blood vessels was about 22%), but plasma exudation was significantly decreased after denervation of RRLN. The left upper side of trachea was decreased by 77.6% and the right upper side decreased by 84.5%. This phenomenon was not caused by denervation of RTVN. The results suggest that vagal nerve innervation of upper trachea mostly came from the RLN.
Otherwise, capsaicin injection into the RTVT also induced neurogenic inflammation in the larynx. Experimental denervation of both superior and recurrent laryngeal nerves resulted in a decrease of plasma extravasation by 84.98%. Denervation of either RTVN or RRLN also decreased the plasma extravasation in the larynx. The evidence suggest that sensory fibers in the superior laryngeal nerve, recurrent laryngeal nerve, and thoracic vagus nerve might come from the same population of vagal ganglion sensory neurons.
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author2 |
Hung-tu Huang |
author_facet |
Hung-tu Huang Yi-Chung Lee 李宜忠 |
author |
Yi-Chung Lee 李宜忠 |
spellingShingle |
Yi-Chung Lee 李宜忠 Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
author_sort |
Yi-Chung Lee |
title |
Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
title_short |
Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
title_full |
Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
title_fullStr |
Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
title_full_unstemmed |
Role of Thoracic Vagal Branches in Regulation of Neurogenic Plasma Leakage in Rat Lower Airway |
title_sort |
role of thoracic vagal branches in regulation of neurogenic plasma leakage in rat lower airway |
publishDate |
2001 |
url |
http://ndltd.ncl.edu.tw/handle/04183134486489386718 |
work_keys_str_mv |
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