the relationship between serum uric acid and cardiovascular disease risk

• Main Authors: Jui-Yao Liu, 劉瑞瑤
• Other Authors: Wei-Chu Chie
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/93916749991709931982

碩士 === 國立臺灣大學 === 流行病學研究所 === 89 === Objective: Hyperuricemia is a common metabolic disorder in population and is often associated with other cardiovascular disease risk factors such as obese, hyperlipidemia, glucose intolerance and hypertension. The causative relationship of serum uric acid with cardiovascular disease still remains a controversy in Western Countries. The objective of this study is to exam the association of serum uric acid and predicted cardiovascular risk from a cross sectional data of a local population. Method: The data of cardiovascular disease risk factors such as age, sex, systolic blood pressure, cigarettes smoking, total serum cholesterol, high density lipoprotein cholesterol, diabetes, left ventricular hypertrophy by electrocardiography were collected from the people aged 40 to 74 years without prevalent cardiovascular diseases in three villages of I-Lan County from April 2000 to June 2001. The cardiovascular diseases prediction model developed from the Framingham Heart Study by Anderson et al was used to predict their incidence and death of cardiovascular diseases within 10 years. Then univariate and multivariate logistic regressions were done to test the association of serum uric acid and risk of cardiovascular diseases. Result: Serum uric acid is associated with cardiovascular disease risk of women in univariate analysis. The association became insignificant after adjusting for age. Serum uric acid is not associated with cardiovascular disease risk of men both in univariate and multivariate analysis. Conclusion: Uric acid is not an independent risk factor of cardiovascular disease.