| Summary: | 碩士 === 台北醫學院 === 保健營養學研究所 === 89 === Dietary protein restriction is known to be beneficial in the preservation of renal function on chronic renal failure. And soy protein has been shown to exhibit absent increase or mild decrease the glomerular filtration rate compared to animal protein.
The objective of this experiment was to examine the effect of different quantity and quality of dietary protein intake on renal function and structure in rats with 5/6-nephrectomy chronic renal failure. Experimental animals were subjected to nephrectomy and fed ether casein or soya, at 20 or 10% levels. The diets were isocaloric with identical fat, sodium, potassium and phosphorus contents.
The rats with chronic renal failure ingesting 10% casein and soya diets both reduce the rate of decrease renal function compared to 20% casein diet as established by plotting the reciprocal of plasma creatinine versus time. And 10% soya diet demonstrated increase serum albumin, falls in serum cholesterol and triglyceride concentrations and decreases blood urea nitrogen, but 10% casein diet significantly increase serum triglyceride.
This study indicates that low soy protein diets improved nutritional status, plasma lipids and decrease the progression of chronic renal failure in rats. And unrestriction soy protein was associated with decrease the progression of chronic renal failure compare to animal-source protein in partially nephrectomized rats but reduce the rate of decrease renal function was prominent in protein restriction.
|
|---|
