Effects of Marathon Race on Salivary Immunoglobulin A and Glutamine

• Main Authors: Cheng-Chi Tsai, 蔡正吉
• Other Authors: Tai-Ger Hsu
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/94557697457137492290

碩士 === 臺北市立師範學院 === 國民教育研究所 === 89 === Effects of Marathon Race on Salivary Immunoglobulin A and Glutamine June, 2001 Student: Chang-Chi Tsai Advisor: Tai-Ger Hsu Abstract Epidemiological data suggest that endurance athletes be at increased risk for upper respiratory tract infection (URTI) following race events. The s-IgA contributes to early protection, by either preventing the virus from penetrating the cell membrane or by opsonizing the viral particle. Marathon runners decreases IgA concentrations in salivay after race. Glutamine is the most important amino acids involved in immune system function. If both s-IgA and glutamine (Gln.) concentrations were decreased, runners will suffer the immune suppression. The aim of this study was to follow changes in salivary immunoglobulin A (s-IgA) and plasma Gln. after marathon race (MR). Eight elite marathon runners in Taiwan (age=27.6 ±4.7 yrs, ht=164.4 ±4.8 cm, wt=62.0 ±4.1 kg, ran=120 ±28.6 km/per week for 7.6 yrs on average) competed in 2000 Taipei International Marathon Race. Blood samples were taken 4 phases separately, sampling (1) before the race, (2) 30 mins , (3) 24 hrs, and (4) 72 hrs after MR. The extensin of changes in leukocytes, neutrophils, and lymphocytes were measured by flow cytometry. S-IgA was analyzed by enzyme-linked immunosorbent assay (ELISA). Gln. and cortisol were analyzed by high performance liquid chromatography (HPLC). Results indicated that the number of leukocytes and neutrophils in peripheral blood within 30 mins of MR rose significantly (p<.05); nevertheless, returned to normal at 24 hrs. MR runners reduced s-IgA concentrations (100%, p<.05) after 30mins of the MR, however were back to baseline after 24 hrs (p<.05). The level of Gln. concentration dramatically fell after 30mins of the MR (25%, p<.05), and were higher than the baseline level until 72 hrs (33.4%, p<.05). In conclusion, MR can temporarily suppress immune function due to the deficit in s-IgA and Gln. concentrations. Key words: marathon race (MR), salivary immnoglobulin A (s-IgA), glutamine (Gln.).