生物鹼乙酸酯衍生物合成研究II
碩士 === 國防大學中正理工學院 === 應用化學研究所 === 90 === ABSTRACT The ester formed by the substituted acetic acid and amino alcohols has been found to be a numbers of potent anticholinergic properties、antispasmodics、psychotomimetic activities and hallucinogenic effect. The general structure is :...
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ndltd-TW-090CCIT05000012015-10-13T17:34:56Z http://ndltd.ncl.edu.tw/handle/64951770865483287989 生物鹼乙酸酯衍生物合成研究II 劉龍生 碩士 國防大學中正理工學院 應用化學研究所 90 ABSTRACT The ester formed by the substituted acetic acid and amino alcohols has been found to be a numbers of potent anticholinergic properties、antispasmodics、psychotomimetic activities and hallucinogenic effect. The general structure is : R1R2R3-C-C=O-O-R4 where R1 is hydroxy、alkyl、halo or alkoxy;R2 is phenyl or substituted phenyl;R3 is cycloalkyl、hydroxycycloalkyl、phenyl or heterocyclic ring; and R4 is piperidyl、pyrrolidyl or piperazidyl. If we construct the different substitutents (R1 , R2 , R3 , and R4), we could get many different compoun- ds. The target molecules that R1 is hydroxy, R2 is phenyl, R3 is isopropyl、cyclopropyl、cyclobutyl、cyclopentyl、cyclohexyl or phenyl, and R4 is piperidyl were studied recently.Their synthesis is followed by the retrosynthesis. We attempted to modify the synthesis methods from literature for obtaining the best methods of more useful derivatives. We adopted three synthesis pathways such as Mitsunobu reaction、Friedel- Craft’s reaction and organomagnesium (Grignard reagents) reaction. In these experiments, the products of the reaction with Grignard reagents have been found that were easily to be synthesized, separated, and produced a high yield ( 30∼40 %).The results are discussed by physical methods in detail. 林生財 郭悅雄 2002 學位論文 ; thesis 140 zh-TW |
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碩士 === 國防大學中正理工學院 === 應用化學研究所 === 90 === ABSTRACT
The ester formed by the substituted acetic acid and amino alcohols has been found to be a numbers of potent anticholinergic properties、antispasmodics、psychotomimetic activities and hallucinogenic effect. The general structure is :
R1R2R3-C-C=O-O-R4
where R1 is hydroxy、alkyl、halo or alkoxy;R2 is phenyl or substituted phenyl;R3 is cycloalkyl、hydroxycycloalkyl、phenyl or heterocyclic ring; and R4 is piperidyl、pyrrolidyl or piperazidyl. If we construct the different substitutents (R1 , R2 , R3 , and R4), we could get many different compoun- ds.
The target molecules that R1 is hydroxy, R2 is phenyl, R3 is isopropyl、cyclopropyl、cyclobutyl、cyclopentyl、cyclohexyl or phenyl, and R4 is piperidyl were studied recently.Their synthesis is followed by the retrosynthesis. We attempted to modify the synthesis methods from literature for obtaining the best methods of more useful derivatives. We adopted three synthesis pathways such as Mitsunobu reaction、Friedel- Craft’s reaction and organomagnesium (Grignard reagents) reaction. In these experiments, the products of the reaction with Grignard reagents have been found that were easily to be synthesized, separated, and produced a high yield ( 30∼40 %).The results are discussed by physical methods in detail.
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林生財 |
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林生財 劉龍生 |
author |
劉龍生 |
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劉龍生 生物鹼乙酸酯衍生物合成研究II |
author_sort |
劉龍生 |
title |
生物鹼乙酸酯衍生物合成研究II |
title_short |
生物鹼乙酸酯衍生物合成研究II |
title_full |
生物鹼乙酸酯衍生物合成研究II |
title_fullStr |
生物鹼乙酸酯衍生物合成研究II |
title_full_unstemmed |
生物鹼乙酸酯衍生物合成研究II |
title_sort |
生物鹼乙酸酯衍生物合成研究ii |
publishDate |
2002 |
url |
http://ndltd.ncl.edu.tw/handle/64951770865483287989 |
work_keys_str_mv |
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1717781821560717312 |