Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome With Hypoxemia

• Main Authors: Chiu, Kuo-Lang, 邱國樑
• Other Authors: 陳祖裕
• Format: Others
• Language: zh-TW
• Published: 2002
• Online Access: http://ndltd.ncl.edu.tw/handle/99403520717177466034

碩士 === 中國醫藥學院 === 醫學研究所 === 90 === Sleep apnea syndrome has been noted since recent several decades. Its characteristic is repeated apneas during sleep that cause arousals. Because of sleep fragmentation, patients have excessive daytime sleepiness. Many studies had shown the relationship between sleep apnea and hypertension, cardiovascular disorders, and stroke. Higher mortality among patients with obstructive sleep apnea syndrome in some study, but it is reduced after adequate therapy. The most common symptoms are snoring, choking, gasping, unrefreshed sleep, and excessive daytime sleepiness. Some patients seek medical consultation due to witnessed apnea during sleep. Polysomnography (PSG) is the gold standard to diagnose sleep apnea syndrome. It can record many parameters, including sleep stages, breathing, heart beats, and pulse oximetry. The mechanism of cardiovascular disorders in sleep apnea is not fully known, but it may be due to the hypoxemia and hemodynamic change during sleep apnea. Many reactions will be induced by hypoxia, and one of them is the vascular endothelial growth factor (VEGF) production. To make clear the relationship between VEGF and sleep apnea may help to understand more about the pathophysiology of cardiovascular disorder of sleep apnea patients. In this study, we collect 40 candidates who performed polysomnography. Three groups were separated according to the PSG. Group A was defined as normal group with normal PSG. Group B was defined as obstructive sleep apnea without severe hypoxemia. Group C was defined as obstructive sleep apnea with severe hypoxemia. Blood sampling were drawn before and after sleep for vascular endothelial and lactate level tests. The results shows there is no significant difference between VEGF and lactate level among these three group eventhough they had marked difference in desaturation. This result is different to some previous study in the Western population. We conclude that there may be difference in the response to hypoxemia between Eastern and Western populations, or we need other more sensible marker. We suggest more and large-sized studies to make clear that if there is any relationship between the different severity of hypoxemia and VEGF production.