The study and synthesis of N-acetyl-leucyl-leucyl-norleucinal derivatives
碩士 === 國立成功大學 === 臨床藥學研究所 === 90 === 英文摘要 P-glycoprotein (Pgp), the multidrug resistance gene (mdr1) product, reduces the intracellular accumulation of a variety of drugs by pumping drugs out of membranes. Studies have demonstrated that hydrophobic tripeptides N-acetyl- leucyl- leucyl-norleucinal (...
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2002
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| Online Access: | http://ndltd.ncl.edu.tw/handle/y5u4jc |
| Summary: | 碩士 === 國立成功大學 === 臨床藥學研究所 === 90 === 英文摘要
P-glycoprotein (Pgp), the multidrug resistance gene (mdr1) product, reduces the intracellular accumulation of a variety of drugs by pumping drugs out of membranes.
Studies have demonstrated that hydrophobic tripeptides N-acetyl- leucyl- leucyl-norleucinal (ALLN), N-acetyl- leucyl-leucyl-methiminal (ALLM) and N-acetyl-leucyl-leucyl-arginal (leupeptin) are Pgp substrates/inhibitors. We would like to synthesize a series of tripeptides (N-acetyl-leu-leu-X ) and to study the interaction between the tripeptides and Pgp.
We employ liquid-phase peptide synthesis method to obtain. We synthesize the N-acetyl-leucyl-leucine benzyl、N-acetyl-leucyl-leucine、N-acetyl-leucyl-leucyl-tryptophanol、N-acetyl-leucyl-leucyl-CBZ-lysinol、 N-acetyl-leucyl-leucyl-phenylalaninol.
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