The Evaluation and Application of Cognitive Function with Visual Long-term Evoked Potentials in Schizophrenic Patients

• Main Authors: Min-Wei Huang, 黃敏偉
• Other Authors: Kuo-Sheng Cheng
• Format: Others
• Language: en_US
• Published: 2002
• Online Access: http://ndltd.ncl.edu.tw/handle/72935693986749712211

碩士 === 國立成功大學 === 醫學工程研究所碩博士班 === 90 === 　Cognitive dysfunction is now generally accepted as a symptom of schizophrenia. Neuropsychological testing has been increasingly applied in the study and clinical treatment assessment in psychiatry. The severer cognitive impairment was, the poorer prognosis was. Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries were often introduced to evaluate the cognitive function, rather than Visual Long-term Evoked Potentials. However, the long latency auditory and visual evoked potentials are seldom used to evaluate cognitive function. The purpose of this study is to discrimination the cognitive function among normal control and treatment schizophrenic patients by image stimulation included Visual Long-term Evoked Potentials. However, the correlation of Visual Long-term Evoked Potentials (VLEP), Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries is prospected to be setup. 　Forty-three schizophrenic patients were recruited as the experimental group of this study. Forty normal persons were chosen to compare twenty-five schizophrenia patients with sex and age matched in the study. The study is to evaluate cognitive function as well as comparison correlation among auditory and visual Long-term Evoked Potentials, Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries. Visual event related potentials (ERPs) were studied during an oddball paradigm, to testify whether cognitive slowing in schizophrenic patients exists and to investigate whether cognitive information processing can be influenced by different responses to an oddball task in patients with schizophrenic patients and normal subjects. All the data will be analyzed by use of SPSS 10.0 version. 　Compared with auditory and visual ERPs in the schizophrenic subjects, P300 amplitude at Fz, Cz and Pz was significantly different. There were also significantly different N100, N200 and P200 latency at Fz, Cz and Pz between auditory and visual ERPs. Cognitive processing reflected by auditory and visual P300 latency and another visual P400 to rare target stimuli were probably indicator for cognitive function in patients with schizophrenia. In our study, the items of “Total number of errors”, “Perseverative errors”, “Non-perseverative errors” in WCST were correlated with N100, P200, N200, P300 and P400 in schizophrenic patients.