Synthesis of New TRicyclic Adenine Derivatives

碩士 === 國立清華大學 === 化學系 === 90 === Synthesis of a new tetrahydrobenzodiazepinone analogs as anti-HIV agent was accomplished. First, 8-bromo-9-(2-chloroethoxymethyl)adenine (10) was prepared by treatment of 6-amino-9-(2-chloroethoxymethyl)purine (7) with bromine in NaOAc buffer solution (0.30 M) and 1...

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Main Authors:	Lui Jei Wang, 王律傑
Other Authors:	Jih Ru Hwu
Format:	Others
Language:	zh-TW
Published:	2002
Online Access:	http://ndltd.ncl.edu.tw/handle/78404318488583245866

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spelling	ndltd-TW-090NTHU00650592015-10-13T10:34:05Z http://ndltd.ncl.edu.tw/handle/78404318488583245866 Synthesis of New TRicyclic Adenine Derivatives 王律傑 Lui Jei Wang 王律傑碩士國立清華大學化學系 90 Synthesis of a new tetrahydrobenzodiazepinone analogs as anti-HIV agent was accomplished. First, 8-bromo-9-(2-chloroethoxymethyl)adenine (10) was prepared by treatment of 6-amino-9-(2-chloroethoxymethyl)purine (7) with bromine in NaOAc buffer solution (0.30 M) and 1,4-dioxane. Nucleophilic substitution of the chlorine atom in 10 produced iodo derivative 12. Reaction of 10 with methoxy or hydroxy group gave derivatives 13 and 15, respectively. Cyclization of compound 13 was performed by addition of catalytic amout of (NH4)2SO4 in hexamethyldisilazane. Jih Ru Hwu 胡紀如 2002 學位論文 ; thesis 48 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國立清華大學 === 化學系 === 90 === Synthesis of a new tetrahydrobenzodiazepinone analogs as anti-HIV agent was accomplished. First, 8-bromo-9-(2-chloroethoxymethyl)adenine (10) was prepared by treatment of 6-amino-9-(2-chloroethoxymethyl)purine (7) with bromine in NaOAc buffer solution (0.30 M) and 1,4-dioxane. Nucleophilic substitution of the chlorine atom in 10 produced iodo derivative 12. Reaction of 10 with methoxy or hydroxy group gave derivatives 13 and 15, respectively. Cyclization of compound 13 was performed by addition of catalytic amout of (NH4)2SO4 in hexamethyldisilazane.
author2	Jih Ru Hwu
author_facet	Jih Ru Hwu Lui Jei Wang 王律傑
author	Lui Jei Wang 王律傑
spellingShingle	Lui Jei Wang 王律傑 Synthesis of New TRicyclic Adenine Derivatives
author_sort	Lui Jei Wang
title	Synthesis of New TRicyclic Adenine Derivatives
title_short	Synthesis of New TRicyclic Adenine Derivatives
title_full	Synthesis of New TRicyclic Adenine Derivatives
title_fullStr	Synthesis of New TRicyclic Adenine Derivatives
title_full_unstemmed	Synthesis of New TRicyclic Adenine Derivatives
title_sort	synthesis of new tricyclic adenine derivatives
publishDate	2002
url	http://ndltd.ncl.edu.tw/handle/78404318488583245866
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Synthesis of New TRicyclic Adenine Derivatives

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