Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma
碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 90 === Abstract Abnormal expression of cell cycle regulatory proteins, such as Cyclin A, has been implicated in the pathogenesis of several types of cancer. We have examined the expression of Cyclin A in oral squamous cell carcinomas (SCCs) using...
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ndltd-TW-090NTU015940122015-10-13T14:41:12Z http://ndltd.ncl.edu.tw/handle/67574168647066112957 Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma CyclinA於口腔鱗狀細胞癌之表現及其預後價值 KaiHung Lin 林凱弘 碩士 國立臺灣大學 臨床牙醫學研究所 90 Abstract Abnormal expression of cell cycle regulatory proteins, such as Cyclin A, has been implicated in the pathogenesis of several types of cancer. We have examined the expression of Cyclin A in oral squamous cell carcinomas (SCCs) using anti-cyclin A antibody with an immunoperoxidase technique. Cyclin A nuclear staining was observed in 57 of the 93 (61.3%) cases of oral SCC. The mean labeling index of cyclin A-positive tumor cells was 21.3 ±12.3% (range 4.5~49.5%). The expression of Cycin A was significantly correlated with increased tumor size (P = 0.0017), lymph node status (P = 0.0006), advanced cancer stage (P = 0.0048) and cancer recurrence (P < 0.0001). The Kaplan-Meier analysis showed that patients with tumors containing more than 15% Cyclin A-positive cells had significantly shorter overall survival than those with tumors containing less than 15% Cyclin A-positive cells (P<0.00001 by Log-rank & Wilcoxon tests). Patients with larger tumor size (T3+T4) had significantly shorter overall survival than those with smaller tumor size (T1+T2) (P = 0.0163). Patients with regional lymph nodes metastasis (LAP(+)) had significantly shorter overall survival than those without regional lymph node metastasis (LAP(-))(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with advanced cancer stages(Stage III + Stage IV) had significantly shorter overall survival than those with lower grade cancer stage(Stage I + Stage II)(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with recurrence of cancer had significantly shorter overall survival than those without recurrence (P < 0.00001 by Log-rank & Wilcoxon tests ). These results indicate that Cyclin A may play an important role in oral carcinogenesis and can also serve a powerful prognostic factor of oral SCCs. Mark Yen-Ping Kuo Chun-Pin Chiang Ying-Shiung Kuo 郭彥彬 江俊斌 郭英雄 2002 學位論文 ; thesis 83 zh-TW |
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碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 90 === Abstract
Abnormal expression of cell cycle regulatory proteins, such as Cyclin A, has been implicated in the pathogenesis of several types of cancer. We have examined the expression of Cyclin A in oral squamous cell carcinomas (SCCs) using anti-cyclin A antibody with an immunoperoxidase technique. Cyclin A nuclear staining was observed in 57 of the 93 (61.3%) cases of oral SCC. The mean labeling index of cyclin A-positive tumor cells was 21.3 ±12.3% (range 4.5~49.5%). The expression of Cycin A was significantly correlated with increased tumor size (P = 0.0017), lymph node status (P = 0.0006), advanced cancer stage (P = 0.0048) and cancer recurrence (P < 0.0001). The Kaplan-Meier analysis showed that patients with tumors containing more than 15% Cyclin A-positive cells had significantly shorter overall survival than those with tumors containing less than 15% Cyclin A-positive cells (P<0.00001 by Log-rank & Wilcoxon tests). Patients with larger tumor size (T3+T4) had significantly shorter overall survival than those with smaller tumor size (T1+T2) (P = 0.0163). Patients with regional lymph nodes metastasis (LAP(+)) had significantly shorter overall survival than those without regional lymph node metastasis (LAP(-))(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with advanced cancer stages(Stage III + Stage IV) had significantly shorter overall survival than those with lower grade cancer stage(Stage I + Stage II)(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with recurrence of cancer had significantly shorter overall survival than those without recurrence (P < 0.00001 by Log-rank & Wilcoxon tests ).
These results indicate that Cyclin A may play an important role in oral carcinogenesis and can also serve a powerful prognostic factor of oral SCCs.
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author2 |
Mark Yen-Ping Kuo |
author_facet |
Mark Yen-Ping Kuo KaiHung Lin 林凱弘 |
author |
KaiHung Lin 林凱弘 |
spellingShingle |
KaiHung Lin 林凱弘 Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
author_sort |
KaiHung Lin |
title |
Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
title_short |
Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
title_full |
Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
title_fullStr |
Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
title_full_unstemmed |
Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma |
title_sort |
prognostic role of cyclin a expression in oral squamous cell carcinoma |
publishDate |
2002 |
url |
http://ndltd.ncl.edu.tw/handle/67574168647066112957 |
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