Prognostic Role of Cyclin A Expression in Oral Squamous Cell Carcinoma

• Main Authors: KaiHung Lin, 林凱弘
• Other Authors: Mark Yen-Ping Kuo
• Format: Others
• Language: zh-TW
• Published: 2002
• Online Access: http://ndltd.ncl.edu.tw/handle/67574168647066112957

碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 90 === Abstract Abnormal expression of cell cycle regulatory proteins, such as Cyclin A, has been implicated in the pathogenesis of several types of cancer. We have examined the expression of Cyclin A in oral squamous cell carcinomas (SCCs) using anti-cyclin A antibody with an immunoperoxidase technique. Cyclin A nuclear staining was observed in 57 of the 93 (61.3%) cases of oral SCC. The mean labeling index of cyclin A-positive tumor cells was 21.3 ±12.3% (range 4.5~49.5%). The expression of Cycin A was significantly correlated with increased tumor size (P = 0.0017), lymph node status (P = 0.0006), advanced cancer stage (P = 0.0048) and cancer recurrence (P < 0.0001). The Kaplan-Meier analysis showed that patients with tumors containing more than 15% Cyclin A-positive cells had significantly shorter overall survival than those with tumors containing less than 15% Cyclin A-positive cells (P<0.00001 by Log-rank & Wilcoxon tests). Patients with larger tumor size (T3+T4) had significantly shorter overall survival than those with smaller tumor size (T1+T2) (P = 0.0163). Patients with regional lymph nodes metastasis (LAP(+)) had significantly shorter overall survival than those without regional lymph node metastasis (LAP(-))(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with advanced cancer stages(Stage III + Stage IV) had significantly shorter overall survival than those with lower grade cancer stage(Stage I + Stage II)(P < 0.00001 by Log-rank & Wilcoxon tests ). Patients with recurrence of cancer had significantly shorter overall survival than those without recurrence (P < 0.00001 by Log-rank & Wilcoxon tests ). These results indicate that Cyclin A may play an important role in oral carcinogenesis and can also serve a powerful prognostic factor of oral SCCs.