Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats
碩士 === 靜宜大學 === 食品營養研究所 === 90 === The purpose of this research was to study the effects of high molecular weight chitosan on lipid digestibility and intestinal physiological functions in rats. Three chitosans ( Mv: 600、300 and 150 kDa ) were prepared from a chitosan(1200 kDa)by enzymatic cleavage u...
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ndltd-TW-090PU0052550052016-06-08T04:13:33Z http://ndltd.ncl.edu.tw/handle/08595948472503793131 Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats 高分子量幾丁聚醣對大白鼠營養素消化率及腸道生理功能之影響 Kuang-Lin Chen 陳廣麟 碩士 靜宜大學 食品營養研究所 90 The purpose of this research was to study the effects of high molecular weight chitosan on lipid digestibility and intestinal physiological functions in rats. Three chitosans ( Mv: 600、300 and 150 kDa ) were prepared from a chitosan(1200 kDa)by enzymatic cleavage under pH 4 at 37 ℃. The degree of deacetylation of these chitosan is approximately 80 %. Five groups of ten Wistar rats were fed a high-fat diet ( 15 % soybean oil ) containing 5 % cellulose (A) and 5 % chitosan with different molecular weight ( B:1200 kDa, C :600 kDa, D:300 kDa, E:150 kDa ) for 4 weeks. Body weight and feed intake were recorded daily. At the end of the experimental period, fecal and blood samples were collected for the analysis of nutrient digestibility and lipid profiles, respectively. When compared to control group, food intake, body weight gain, epidiymal fat pad weight, apparent digestibility of fat and protein were decreased significantly in the chitosan-fed groups. In addition, total fecal weight, fecal moisture and lipid content, cecal wall weight were increased by chitosan feeding. However, blood total cholesterol, LDL and HDL concentrations were not affected by the addition of chitosan in feed. These results suggest that intake of high molecular weight chitosan can prevent body weight gain and body fat accumulation in rats under high-fat feeding condition. Kung-Chu Chan 詹恭巨 2002 學位論文 ; thesis 90 zh-TW |
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碩士 === 靜宜大學 === 食品營養研究所 === 90 === The purpose of this research was to study the effects of high molecular weight
chitosan on lipid digestibility and intestinal physiological functions in
rats. Three chitosans ( Mv: 600、300 and 150 kDa ) were prepared from a
chitosan(1200 kDa)by enzymatic cleavage under pH 4 at 37 ℃. The degree of
deacetylation of these chitosan is approximately 80 %. Five groups of ten
Wistar rats were fed a high-fat diet ( 15 % soybean oil ) containing 5 %
cellulose (A) and 5 % chitosan with different molecular weight ( B:1200 kDa, C
:600 kDa, D:300 kDa, E:150 kDa ) for 4 weeks. Body weight and feed intake
were recorded daily. At the end of the experimental period, fecal and blood
samples were collected for the analysis of nutrient digestibility and lipid
profiles, respectively. When compared to control group, food intake, body
weight gain, epidiymal fat pad weight, apparent digestibility of fat and
protein were decreased significantly in the chitosan-fed groups. In addition,
total fecal weight, fecal moisture and lipid content, cecal wall weight were
increased by chitosan feeding. However, blood total cholesterol, LDL and HDL
concentrations were not affected by the addition of chitosan in feed. These
results suggest that intake of high molecular weight chitosan can prevent body
weight gain and body fat accumulation in rats under high-fat feeding condition.
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author2 |
Kung-Chu Chan |
author_facet |
Kung-Chu Chan Kuang-Lin Chen 陳廣麟 |
author |
Kuang-Lin Chen 陳廣麟 |
spellingShingle |
Kuang-Lin Chen 陳廣麟 Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
author_sort |
Kuang-Lin Chen |
title |
Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
title_short |
Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
title_full |
Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
title_fullStr |
Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
title_full_unstemmed |
Effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
title_sort |
effect of high molecular weight chitosan on nutrient digestibility and intestinal physiological function in rats |
publishDate |
2002 |
url |
http://ndltd.ncl.edu.tw/handle/08595948472503793131 |
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