| Summary: | 碩士 === 大同大學 === 化學工程研究所 === 90 === A silane monomer 3-acrylamidopropyltrimethixysilane (APTMOS) having amido group and methoxy group was prepared for comparing with 3-methacryloxypropyltrimethoxysilane (MPTMOS) having ester group and methoxy group. A series of (N-isopropylacrylamide)-SiO2 copolymeric hydrogels were prepared from copolymerization of NIPAAm/3-acrylamidopropyltrimethoxysilane and NIPAAm/3- methacryloxypropyltrimethoxysilane, and the swelling behaviors and mechanical properties were investigated. The hybrid gels exhibited temperature dependence to the content of silane monomers. Swelling ratios and mechanical strength were influenced with the content of silane monomers in the hybrid gels. Swelling ratios were also affected by the monomer concentration, amount of crosslinker, and the environmental solution.The drug release behaviors were also investigated by changing silane content in the copolymeric hydrogels, drug species, monomer concentration, and temperature modulation. The results showed that the release ratios of copolymeric hydrogels containing siloxane structure were influenced by the interaction between gel and drug, the compactness of gel network, release temperature, monomer concentration, and the time of drug loading.
Another series of porous hydrogels were prepared by adding porosigen by emulsion polymerization. For porous NIPAAm hydrogels, the addition of porosigen would increase the swelling ratios. But adding porosigen in the copolymeric hydrogels containing silyl group would obtain reverse effect to the gels that the swelling ratios decreased. PEG having different molecular weight also affected the swelling ratios of the porous hydrogels. The higher the Mw of the porosigen added in the feed, the higher the swelling ratio of the gels performed. In the fast swell-deswell test, porous hydrogels with more porosigen had faster response to temperature, that is, they had faster swelling and deswelling rate than gels with fewer porosigen. Porous hydrogels dried by freeze drying had high swelling ratios and fast swell-deswell kinetics. In drug release behaviors, investigated the effects of amount of porosigen and drying treatments on the release ratio and release rate of the porous hydrogels. The release ratio and release rate of porous hydrogels increased with increasing of the amount of porosigen. The porous hydrogels dried by freeze drying had higher release ratio and faster release rate than the gels that dried by conventional method.
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