| Summary: | 碩士 === 中國醫藥學院 === 中國醫學研究所 === 91 === Effect of Chinese Medicine for Supplementing
Yin and Qi on Regeneration of Dissected Rat
Sciatic Nerve Repaired with Silicone tube
Huei-Chun Tsai
Major professor: Yueh-Sheng Chen
Institute of Chinese Medical Science, China Medical College
If the neurotmesis is not properly treated, the neuroma can happen. The gap length between the injured nerve ends is the most important factor in deciding the suturing methods of repairing severed peripheral nerve. End-to-end suturing and fasicular suturing methods are suitable to the shorter gaps. As for the large gaps, nerve grafting and nerve bridging methods are suggested. It is difficult to get the original source of nerve grafting method so that it is better choice to use nerve bridging method to repair the large gap of both ends of severed nerve.
Nerve bridging technique is to put both ends of severed nerves in a tube, which can guide and support nerve fiber regeneration. There are many kinds of materials used for nerve guide tubes, such as the silicone tube which is most commanly used.
There are several phisiological similarities between flaccidity commonly seen in Chinese medicine and the condition after cutting the peripheral nerve. It is believed that both the symptoms could be with the same basic causes. To cure the flaccidity, drugs for replenishing Qi, Blood, Yin and Yang are used in Chinese medicine.
In the present study, Luh-Wey-Dih-Hwang-Wuang, a Chinese formula to supplement Yin was fed to the rats, whose sciatic nerves had been dissected for 1 cm and repaired with silicone tubes for eight weeks of implantation. In addition, Si-Jiun-Zi-Tang, a Chinese formula to replenish Qi was also tested to clarify the actual role of Chinese medicine for tonocity on nerve regeneration. As a result, it was found that the success percentages of regeneration occurred in the groups of the Luh-Wey-Dih-Hwang-Wuang, the Si-Jiun-Zi-Tang and the control were 62.5%, 37.5% and 40%, respectively. This finding demonstrated that Luh-Wey-Dih-Hwang-Wuang can promote nerve regeneration. But Si-Jiun-Zi-Tang and the control had better result in maturity of regenerated nerve than Luh-Wey-Dih-Hwang-Wuang.
Key word: peripheral nerve regeneration; silicone tube;
Luh-Wey-Dih-Hwang-Wuang; Si-Jiun-Zi-Tang
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