Selective N-debenzylation of amide with p-TsOH
碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Abstract A new efficient method for the N-debenzylation of N-2,4-dimethoxylbenzyl amide is described using 4 equivalences of ρ-TsOH in refluxing toluene. It is applicable to wide varieties of compounds including primary, secondary, tertiary, phenyl, and styryl...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2003
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| Online Access: | http://ndltd.ncl.edu.tw/handle/zx5w5g |
| Summary: | 碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Abstract
A new efficient method for the N-debenzylation of N-2,4-dimethoxylbenzyl amide is described using 4 equivalences of ρ-TsOH in refluxing toluene. It is applicable to wide varieties of compounds including primary, secondary, tertiary, phenyl, and styryl carboxyamides. Good to quantitative yields of the desirable amides were usually obtainable within 4 hours.
In the meantime extend this method to afford ene-lactam compounds with some modifications. Moreover, we plan to investigate the mechanism of the N-debenzylation of N-2,4-dimethoxylbenzyl amide promoted by ρ-TsOH
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