Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A

碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Saframycin A (1a) is one kind of natural products which show potent antitumor antibiotics. Due to the scant availability from natural sources and difficulty in cultivation, we make an attempt to synthsize derivatives of the Saframycin A (1a) by means of organic...

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Main Authors:	Meng-Tsung Li, 李孟宗
Other Authors:	none
Format:	Others
Language:	zh-TW
Published:	2003
Online Access:	http://ndltd.ncl.edu.tw/handle/zyvy23

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spelling	ndltd-TW-091CYUT55000082018-06-25T06:06:27Z http://ndltd.ncl.edu.tw/handle/zyvy23 Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A 抗癌天然物沙弗拉黴素(SaframycinA)重要中間體之合成研究 Meng-Tsung Li 李孟宗碩士朝陽科技大學應用化學系碩士班 91 Saframycin A (1a) is one kind of natural products which show potent antitumor antibiotics. Due to the scant availability from natural sources and difficulty in cultivation, we make an attempt to synthsize derivatives of the Saframycin A (1a) by means of organic synthesis. The main purpose of this study is to utilize an inexpensive, exhibiting stereo-controlled substance, being a natural amino acid L-tyrosine as a starting material which could be transformed into the key intermediate 34b an optically active dizobicyclo [3.3.1] nonane. 34b may be further transformed to compound 33 which has been synthesized by Dr. E. J.Corey, and subsequently 33 was converted to Saframycin A (1a). none 卓重光 2003 學位論文 ; thesis 141 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Saframycin A (1a) is one kind of natural products which show potent antitumor antibiotics. Due to the scant availability from natural sources and difficulty in cultivation, we make an attempt to synthsize derivatives of the Saframycin A (1a) by means of organic synthesis. The main purpose of this study is to utilize an inexpensive, exhibiting stereo-controlled substance, being a natural amino acid L-tyrosine as a starting material which could be transformed into the key intermediate 34b an optically active dizobicyclo [3.3.1] nonane. 34b may be further transformed to compound 33 which has been synthesized by Dr. E. J.Corey, and subsequently 33 was converted to Saframycin A (1a).
author2	none
author_facet	none Meng-Tsung Li 李孟宗
author	Meng-Tsung Li 李孟宗
spellingShingle	Meng-Tsung Li 李孟宗 Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
author_sort	Meng-Tsung Li
title	Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
title_short	Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
title_full	Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
title_fullStr	Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
title_full_unstemmed	Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
title_sort	synthetic studies on the key intermediate of potent anti-tumor natural products-saframycin a
publishDate	2003
url	http://ndltd.ncl.edu.tw/handle/zyvy23
work_keys_str_mv	AT mengtsungli syntheticstudiesonthekeyintermediateofpotentantitumornaturalproductssaframycina AT lǐmèngzōng syntheticstudiesonthekeyintermediateofpotentantitumornaturalproductssaframycina AT mengtsungli kàngáitiānránwùshāfúlāméisùsaframycinazhòngyàozhōngjiāntǐzhīhéchéngyánjiū AT lǐmèngzōng kàngáitiānránwùshāfúlāméisùsaframycinazhòngyàozhōngjiāntǐzhīhéchéngyánjiū
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Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A

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