In Vitro Study of a Polyester Weft-Knitted Fabric Coated with Chitosan for Biomedical Materials

• Main Authors: Cai-Lian Chen, 陳彩蓮
• Other Authors: Yueh-Sheng Chen
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/376j9d

碩士 === 逢甲大學 === 紡織工程所 === 91 === Abstract Synthetic materials used for medical purposes are called biomaterials. Using the biomedical and tissue engineering techniques, fibrous textiles can be made for medical usage. For example, porous fibrous textile can be a framework for cells to adhere and grow into. In this study, we first made woven samples with different structures fabricated at different conditions. Their mechanical properties, porosity, and permeability were investigated. We then coated chitosan on the samples and their drug release patterns were studied. In addition, cytotoxicity of the coated samples was evaluated. Materials used in this study were divided into 4 groups. The A group was fed one end with yarn count 75D/ 144f in each feeding point; B group was fed two ends with yarn count 75D/ 144f in each feeding point; C group was fed one end with yarn count 150D/ 144f in each feeding point; D group was fed two ends with yarn count 150D/ 144f in each feeding point. Moreover, five different fabric structures were designed and presented as structure 1~ 5. They were plain (1), tuck (2), horizontal double tucking (3), vertical double tucking (4), horizontal and vertical double tucking (5) respectively. As a result, we found the structures 3 and 5 of the samples had the largest tensile tenacity in the warp direction and the lowest in the weft direction. However, opposite trends were seen in the structures 1, 2, and 4. After coating, the tenacity of fabrics was decreased slightly and the air permeability was decreased by 1~1.5 times. The ratio of elongation of the coated sample in the warp and the weft directions was close to 1. In the drug release test, all samples except those in the D group showed that the chitosan was released fast from the 2nd to the 3rd as well as from the 7th to the 8th day. In these periods, structures 1,4, and 5 had a higher release rate as compared to that in structures 3 and 5. Finally, we found the released chitosan was not deleterious to the cultured fibroblasts.