The Study on Associated Factors of Gout Recurrence in Taiwan Aborigines

• Main Authors: Yi-Hsin Chen, 陳怡馨
• Other Authors: Shun-Jen Chang
• Format: Others
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/49542870956895704421

碩士 === 高雄醫學大學 === 公共衛生學研究所 === 91 === Abstract This study investigated gout recurrence and associated factors of gout recurrence in Taiwan aborigines. There are two aboriginal tribes (Atayal, Bunun) included as the study population. We collected 110 cases of gout and 150 controls of sex- , tribe- and age-matched in the cross section study. We analyzed the relationships between social demographic data, whole blood biochemical examination, alcohol dehydrogenase 2, alcohol dehydrogenase 3, and aldehyde dehydrogenase 2 polymorphisms and gout recurrence. After the stepwise logistic regression model adjusted the confounders , the results showed that the following factors were significantly in statistics related to gout: 1. hypertension (Odds Ratio=4.8，95%CI=1.4-15.7) , 2. creatinie>=1.5mg/dl (Odds Ratio=13，95%CI=1.2-145), 3. hyperuricemia (Odds Ratio=4.1，95%CI=1.2-14.2), 4. ALDH2*2 (Odds Ratio=26，95%CI=4.2-167). The results showed the gout recurrence rate in recent a year was 96%, and the gout recurrence rate in recent a month was 71%. After the preliminary analysis that factors related to gout recurrence included 1. tribe (Odds ratio=3.2，95%CI=1.4-7.7), 2. age>=40 years old (Odds ratio=2.8，95%CI=1.2-6.7), 3. tatol alcohol amount in log (Odds ratio=4.1，95%CI=1.0-16.3), 4. tophus(Odds ratio=3.4，95%CI=1.1-10.3), 5. ALDH2*non2 (Odds ratio=2.6，95%CI=1.02-7.0). After the stepwise logistic regression model adjusted the confounders, only showed that only ALDH2*non2 (Odds ratio=12.2，95%CI=1.2-117.4) was a associated factor of gout recurrence. This study concluded that the associated factors of gout in Taiwan aborigines included hypertension, creatinie, hyperuricemia and ALDH2*2. On the other hand, ALDH2*2 was a protect factor of the association of gout recurrence in Taiwan aborigines.