Assessment on Type 2 Diabetes Mellitus with Chinese Medicine Formulas

• Main Authors: Chia-Ying Chao, 趙家瑩
• Other Authors: Thau-Ming Cham
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/6qbrxy

碩士 === 高雄醫學大學 === 藥學研究所 === 91 === Background: Diabetes mellitus is the fourth leading cause of death in Taiwan (2002). We had focused on the needs of people with type 2 diabetes— the rapidly increasing prevalence of which should be a major concern for health- care providers. Traditional Chinese medicine, used in Taiwan for centuries, was used for many diseases, including type 2 diabetes mellitus. Because the morbidity and mortality remained terrible in the modern treating model, the benefits of Chinese formulas in preventing and delaying the development and progression of diabetic complications had been well expected. We used three Chinese medicine formulas (DM1, DM2 and DM3) to the type 2 diabetic outpatients in this study. Objective: The purpose of this study was to investigate the effects and side effects of Chinese medicine formulas on type 2 diabetic outpatients with laboratory examinations. Methods: All of the diabetic patients took a formula of Chinese medicine, concentrated powder 20 g/day, divided by four times for 16 weeks in this study. DM1 was used for dryness and heat of lung and stomach, marked by extreme thirst and excessive drinking, dry mouth and tongue, red tongue with yellow- dry coating and rapid- strong pulse. DM2 was used for deficiency of kidney- yin, marked by polyuria, extreme thirst and excessive drinking, dizziness, waist- soreness, soreness and numbness of extremities, blurred vision, red tongue with little coating, deep and thready pulse. DM3 was used for deficiency of qi and yin, marked by polyuria, extreme thirst and excessive drinking, fatigue, red tongue with little and white coating, deep and thin pulse. Results: 31 type 2 diabetic outpatients 16-76 years old participated in the study. The mean age of the patients was 52.711.2 (17-76) years. The mean BMI was 24.23.6 (Kg/m2). The mean duration of diabetes was 6.4±6.1 years. Before treatment, the mean glycosylated A1C (HbA1C normal 4.4-6.4%) of group DM1 was 9.22±2.80% (week 0). After treatment 16 weeks, the mean HbA1C was 7.43±1.88%. There was a significant decreasing trend in HbA1C after treatment 16 weeks (p< 0.05). Before treatment, the mean HbA1C of all patients was 8.73±2.63% (week 0). After treatment 12 and 16 weeks, the mean HbA1C was 7.31±1.61% and 7.25±1.63% respectively. There were significant decreasing trends in HbA1C After treatment 12 and 16 weeks (p< 0.05). Before treatment, the mean fasting plasma glucose (FPG normal 70-110 mg/dl) of group DM2 was 185.2±91.9 mg/dl (week 0). After treatment 14 and 16 weeks, the mean was 130.6±10.1 mg/dl and 122.3±13.0 mg/dl respectively. There were significant decreasing trends in FPG after treatment 14 and 16 weeks (p< 0.05). Before treatment, the mean fasting plasma glucose of all patients was 193.3±86.1 mg/dl (week 0). After treatment 10, 12, 14 and 16 weeks, the mean was 159.1±50.4 mg/dl, 158.1±51.3 mg/dl, 145.3±34.1 mg/dl, 145.3±49.0 mg/dl respectively. There were significant decreasing trends in FPG after treatment 10 weeks (p< 0.05). The plasma LDL and VLDL were in the normal range in the 16 weeks period. Before treatment, the mean cholesterol (normal 140- 200 mg/dl) of group DM2 was 207.4±61.7 mg/dl (week 0). After treatment 16 weeks, the mean was 164.5±23.9 mg/dl. There was a significant decreasing trend in cholesterol after treatment 16 weeks (p< 0.05). Before treatment, the mean triglyceride (normal 50-150 mg/dl) of group DM2 was 216.7±201.4 mg/dl (week 0). After treatment 12 and 16 weeks, the mean was 99.0±53.5 mg/dl and 53.0±6.2 mg/dl respectively. There were significant decreasing trends in TG after treatment 12 and 16 weeks (p< 0.05). The renal function tests and the liver function tests of all patients were not elevated in the 16-week treating period. Conclusion: There were several beneficial effects of traditional Chinese medicine observed. There was better decreased in HbA1C in the group DM1. There were better decreased in FPG, cholesterol and TG in the group DM2. There were no elevated liver function tests and renal function tests in the 16- week treating period. We will design a randomized, placebo- controlled study and collected more patients in the future to determine the effects and side effects of Chinese medicine.