| Summary: | 碩士 === 國立成功大學 === 行為醫學研究所 === 91 === Depression and anxiety disorders are widely studied in the psychological aspects. Previous family twin studies had suggested that genetic basis plays an important role in depression and anxiety disorders. But in linkage studies, the findings are not consistent. Serotonin is the biogenic amine neurotransmitter most commonly associated with depression and anxiety. The human tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis, thus it has been a candidate gene for genetic research with various psychiatric disorders. SNPs are major contributors to genetic variation and mutationally more stable, making them suitable for association studies in which linkage disequilibrium (LD) between markers and an unknown variant is used to map disease-causing mutations. The aim of this study is to examine if major depression, anxiety disorders and comorbid depression and anxiety is related to genetic variations in human TPH gene. In this study, 206 females from a postpartum depression study, which were classified into depression, anxiety, comorbid anxiety and depression, and normal control, were also collected. Five SNP markers within and around TPH gene were genotyped using two fast and convenient genotyping methods. Genotyping results were analyzed with chi-square analysis to examine to association between groups. Result of this study suggested that TPH may not play an important role in the etiology of depression, anxiety and comorbid depression and anxiety in our population. However, further study may be required to investigate if TPH has minor regulatory effect in the pathogenesis of these psychiatric disorders.
|
|---|
