Assessing regional pulmonary perfusion by dynamic contrast-enhanced MR imaging

• Main Authors: Tsai Shang-Yueh, 蔡尚岳
• Other Authors: Chung Hsiao-Wen
• Format: Others
• Language: en_US
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/82919968696908005425

碩士 === 國立臺灣大學 === 電機工程學研究所 === 91 === Dynamic contrast-enhanced MR imaging with millisecond TE has been shown effective to assess relative pulmonary perfusion. Using this method, mean transit time, pulmonary blood volume, and pulmonary blood flow were calculated. In this study two computational methods that evaluate regional lung perfusion distribution from pulmonary arteries and veins are proposed. The accuracy of these methods is examined by the computer simulations. It is indicated by the simulation that deconvolution based on singular value decomposition is prone to estimation errors, whereas subtraction of mean transit time yields reliable measurements. The correlation analysis is employed to identify pulmonary arteries and veins. Experimental data from healthy subjects show consistently shorter mean transit time with similar pulmonary blood flow in the superior lung parenchyma compared with the inferior region