| Summary: | 碩士 === 中國醫藥大學 === 藥物化學研究所 === 92 === In order to develop the novel leukemia cell differentiation agents, a series of 3,6-subsituted 9-pyridylmethylcarbazole derivatives was been screened for their induced differentiation and growth inhibition activities of HL-60 cells. According to the results, when using compound HYL-3b along, it was the most effective to differentiation compared with the other compounds. And it is shown the great coefficient effect to differentiation when combined with all-trans retinoic acid (ATRA). Therefore, the further studies of action mechanism were carried out to evaluate its effects on the cell cycle of HL-60 cells.
When treatment of compound HYL-3b alone, it was found to affect the cell cycle as the same way of ATRA, which induced G0/ G1 phase arrest of HL-60 cells.
This finding suggests that compound HYL-3b maybe has great potential in the treatment of acute promyelocytic leukemia (APL) either dose alone or together with ATRA.
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