| Summary: | 碩士 === 中山醫學大學 === 生物化學研究所 === 92 === 英文摘要（Abstract in English）
Lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria, is a potent activator of monocytes and macrophages. Upon LPS stimulation, macrophages are provoked to secrete reactive nitrite, and a variety of cytokines, to undergo morphological alteration that results in migration, and to proceed phagocytosis. As a popular dietary spice in the East, curcumin is also a well-known anti-inflammatory agent. In this study, we observed that curcumin inhibited the LPS-meditated morphological alteration that culminated to cellular migration in both Raw264.7 cells and peritoneal macrophages. Concurrent to this phenomenon was the abrogation of LPS-elicited protein tyrosyl phosphorylation upon curcumin exposure. Intriguingly, curcumin could inhibit the LPS-induced c-Src expression that believed to contribute to macrophage activation. To our knowledge, this is the first report that curcumin can suppress LPS-elicited macrophage migration via attenuation of c-Src induction mediated by LPS.
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