Investigation on Aspergillus terreus immobilization using cell entrapment method

• Main Authors: Sheng-leh Chen, 陳盛樂
• Other Authors: Long-shan T. Lai
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/5qc99b

碩士 === 朝陽科技大學 === 應用化學系碩士班 === 92 === Abstract Cell entrapment of Aspergillus terreus by calcium alginate unexpectedly decrease lovastatin production. More specially, if intracellular protein content was used as cell growth index, the protein content was found to be less than the control group(free suspension culture). It implied that cell growth was inhibited after cell entrapment. Meanwhile, the titre was largely reduced as only 100 mg/l, one-sixth of that in the control group. The pH of cell-immobilized group maximized one day later as compared with that of the control group, probably because of the existence of barrier layer, which caused resistance to untrient transport of nutrients. 【Key words】: Calcium alginate , Fungal cell immobilization (entrapment method)