The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells
博士 === 高雄醫學大學 === 天然藥物研究所 === 92 === Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also one of the four most prevalent malignant diseases of adults in China, Taiwan, Korea, and Sub-Africa. This research project was divided into three portions. For the first...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Published: |
2004
|
Online Access: | http://ndltd.ncl.edu.tw/handle/12291329110700283498 |
id |
ndltd-TW-092KMC00068002 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-092KMC000680022016-01-04T04:09:18Z http://ndltd.ncl.edu.tw/handle/12291329110700283498 The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells 數種天然藥物之純化成分對人類肝癌細胞增生抑制作用和細胞程式死亡機制之探討 Po-Lin Kuo 郭柏麟 博士 高雄醫學大學 天然藥物研究所 92 Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also one of the four most prevalent malignant diseases of adults in China, Taiwan, Korea, and Sub-Africa. This research project was divided into three portions. For the first step, we plan to assay the antiproliferative effects of aloe-emodin, resveratrol, EGCG ((-)-epigallocatechin-3-gallate), tetrandrine and rhein in two human liver cancer cell lines, Hep G2 and Hep 3B, and determine the time- and dose-dependent responses. We also examined these compounds, for the study of their impacts on cell growth and cell cycle progression. For the second and third steps, to provide a better understanding of the anticancer effect in molecular basis, we assayed several target molecules such as p53, p21, Fas ligand, Fas receptor, Bcl-2, Bax, which were strongly associated with apoptotic pathway and were believed having something to do with the chemosensitivity’s efficacies upon anticancer drug therapy. Chun-Ching Lin 林俊清 2004 學位論文 ; thesis 96 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
博士 === 高雄醫學大學 === 天然藥物研究所 === 92 === Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also one of the four most prevalent malignant diseases of adults in China, Taiwan, Korea, and Sub-Africa.
This research project was divided into three portions. For the first step, we plan to assay the antiproliferative effects of aloe-emodin, resveratrol, EGCG ((-)-epigallocatechin-3-gallate), tetrandrine and rhein in two human liver cancer cell lines, Hep G2 and Hep 3B, and determine the time- and dose-dependent responses. We also examined these compounds, for the study of their impacts on cell growth and cell cycle progression. For the second and third steps, to provide a better understanding of the anticancer effect in molecular basis, we assayed several target molecules such as p53, p21, Fas ligand, Fas receptor, Bcl-2, Bax, which were strongly associated with apoptotic pathway and were believed having something to do with the chemosensitivity’s efficacies upon anticancer drug therapy.
|
author2 |
Chun-Ching Lin |
author_facet |
Chun-Ching Lin Po-Lin Kuo 郭柏麟 |
author |
Po-Lin Kuo 郭柏麟 |
spellingShingle |
Po-Lin Kuo 郭柏麟 The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
author_sort |
Po-Lin Kuo |
title |
The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
title_short |
The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
title_full |
The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
title_fullStr |
The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
title_full_unstemmed |
The proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
title_sort |
proliferative inhibition and apoptotic mechanism of several natural products in human hepatoma cells |
publishDate |
2004 |
url |
http://ndltd.ncl.edu.tw/handle/12291329110700283498 |
work_keys_str_mv |
AT polinkuo theproliferativeinhibitionandapoptoticmechanismofseveralnaturalproductsinhumanhepatomacells AT guōbǎilín theproliferativeinhibitionandapoptoticmechanismofseveralnaturalproductsinhumanhepatomacells AT polinkuo shùzhǒngtiānrányàowùzhīchúnhuàchéngfēnduìrénlèigānáixìbāozēngshēngyìzhìzuòyònghéxìbāochéngshìsǐwángjīzhìzhītàntǎo AT guōbǎilín shùzhǒngtiānrányàowùzhīchúnhuàchéngfēnduìrénlèigānáixìbāozēngshēngyìzhìzuòyònghéxìbāochéngshìsǐwángjīzhìzhītàntǎo AT polinkuo proliferativeinhibitionandapoptoticmechanismofseveralnaturalproductsinhumanhepatomacells AT guōbǎilín proliferativeinhibitionandapoptoticmechanismofseveralnaturalproductsinhumanhepatomacells |
_version_ |
1718160284133097472 |