| Summary: | 碩士 === 高雄醫學大學 === 天然藥物研究所碩士班 === 92 === Abstract
Peucedanum formosanum Hay. (Umbelliferae) is an endemic perennial herb in Taiwan, distributes at medium to high altitudes through the Island. Its root was used as folk medicine to treat cough, fever, headache and sputum caused by colds like the traditional Chinese medicine, Qain Hu. The methanolic extract of the root showed anti-platelet aggregation activity in preliminary screening. Investigation on the MeOH extract of the root led to the isolation of one saccharide, D-mannitol (1) from theparcipitate portion, thirty-one known compounds including coumarins bergapten (2), isoimperatorin (3), (–)-deltoin (4), xanthotoxin (5), praeruptorin E (8), hyuganin A (9), (–)-peujaponisin (10), (–)-isosamidin (11), (+)-peuformosin (12), (+)-anomalin (13), (+)-cis-3’-acetoxy-4-(2-methylbutyroyloxy)-3’,4’-dihydroseselin (14), cis-3’-hydroxy-4’-isovaleryloxy-3’,4’-dihydroseselin (15), laserpitin (16), (–)-cis-3’-hydroxy-4’-(2-methyl-butyroyloxy)-3’,4’-dihydroseselin (17), (+)-marmesin (18), isoscopoletin (19), umbelliferone (20), psoralen (24), (+)-lomatin (25), isofraxidin (26), (–)-cis-khellactone (27), (+)-3’-hydroxymarmesin (28), (+)-rutaretin (29), (+)-oxypeucedanin hydrate (30), and (+)-dorsteniol (31); one monoglyceride, 1-O-hexadecanoyl glycerol (32); mixture of β-sitosterol (6) and stigamasterol (7); two polyacetylenes falcaridiol (22), and panaxynol (23); one benzenoid, p-hydroxyphenethyl ferulate (21). The structures of isolates were elucidated by spectroscopic analysis.
Among the isolates, compounds (2), (3), (4), (5), (18), (20), (24), (26) and (30) with anti-platelet aggregation activity were previously reported by our lab. The anti-platelet aggregation activity of (13), (22), (23) and (27) were also reported by other groups. Compouds (11) and (12) showed anti-platelet aggregation activity induced by collagen.
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