| Summary: | 碩士 === 國立中興大學 === 食品科學系 === 92 === ABSTRACT
Acute-ischemic stroke is a clinical condition frequently accompanied by inflammation and oxidative stress. Although both the antioxidant levels and inflammation status in the plasma after acute ischemic stroke could be correlated with stroke outcome, more studies are required to clarify their relationships. We investigated lipophilic antioxidants (Retinol, Lycopene, a-carotene, b-carotene, g-tocopherol and a-tocopherol) levels in 68 acute-ischemic stroke patients who was admitted to the Neurological Ward of the Chi-Mei Medical Center of Tainan, Taiwan, within 48 hours after stroke onset, and 41 normal controls from relatives of outpatients or hospital employees between April 2002 and August 2003. Absolute and cholesterol-adjusted plasma a- and b-carotene concentrations were low among acute- ischemic stroke patients, as compared with normal controls. The levels of the inflammatory markers (high sensitive C-reactive protein, fibrinogen, erythrocyte sedimentation rate, and white blood cell count) were significantly higher in acute-ischemic stroke patients than in the control subjects. Plasma concentrations of a- and b-carotene in acute-ischemic stroke patients were negatively associated with level of high sensitive C-reactive protein (hs-CRP) (R=-0.29 and —0.41 respectively, p<0.01) and neurological deficits indicated by the score of the National Institute of Health (NIH) stroke scale (R= -0.28 and —0.27 respectively, p<0.05). The negative association between combined plasma levels of a- and b- carotene and the score of the NIH stroke scale remained after adjusted for age and sex (p=0.04). However, the magnitude of association decreased after adjustment of hs-CRP (p=0.08) and no significant association appeared after stroke type was further adjusted (p=0.19). Furthermore, by the analysis of multivariate linear regression, we found that large-artery stroke type was a better predictor of worsened neurological deficits than were hs-CRP and a- and b-carotene combined.
In conclusion, plasma concentrations of a- and b-carotene are lower in acute-ischemic stroke patients and are correlated with higher CRP levels and neurological deficits at the time of discharge. However, stroke type is a better predictor of worsened neurological deficits after acute ischemic stroke than carotenes or hs-CRP.
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