Studies on the Natural Products of a Formosan Soft Coral

• Main Authors: Yen-ju Tseng, 曾彥儒
• Other Authors: Jyh-horng Sheu
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/48274501948674202465

碩士 === 國立中山大學 === 海洋資源學系研究所 === 92 === The chemical constituents of organic extracts of a Formosan soft coral Sinularia lochmodes (Kolonko) (collected at Ken-Ting in Taiwan) was studied and isolated twelve nature compounds (1–12), including seven new compounds, lochmodesolides A–E (1–5), 4,6-dibromo-(2'',5''- dibromophenoxy) anisole (6), 3β,11-dihydroxy-5β,6β-expoxy-24- methylene-9,11-secocholestan-9-one (7), and five know compounds (8–12),(1R*,5R*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene-10,12-carbolactone (8), (1R*, 5S*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5, 8-epoxycyclotetradec-12-ene-10,12-carbolactone (9), norcembrenolide 5 (10), scabrolides A (11), ineleganolide (12). The structures of 1–12 were elucidated by spectroscopic evidences (1D NMR, 2DNMR, IR and MS) and chemical method. The stereochemistry of compound 5 was further confirmed by single-crystal X-ray diffraction analyses. Compounds 8 and 9 showed moderate cytotoxicity against KB, Hela, Med, NCI, DLD-1 and Hepa59T/VGH cancer cell lines.