Prognostic Markers for Upper Urinary-Tract Transitional Cell Carcinoma

• Main Authors: Jui-Hung Chu, 朱瑞虹
• Other Authors: Chin-Yuan Tzen, MD, Ph. D.
• Format: Others
• Language: en_US
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/27617378786990466008

碩士 === 國立台北護理學院 === 醫護管理研究所 === 92 === Foreign researches have demonstrated that the gene mutation will not only induce cancer of certain organs, but also affect the prognosis and recurrence of cancer, and therefore will increase the mortality. In the U.S., the gene screening has already been popularly performed. Through the gene screening, we can find out the abnormal gene, and give the appropriate treatments to the patients in the early periods. If the cancer can be preventive or be treated in the early stage, the patients with cancer can get a better prognosis, thus, we can save the cost to treat the patients with worst situation, then the cost of the National Health Insurance (全民健保) can be reduced effectively. The study will integrate comprehensively with the tumor markers and the prognosis situation of the upper urinary-tract cancer patients, and the purpose of this study is to find out the relationship between the upper urinary-tract cancer and the related tumor markers: which tumor markers will affect the prognosis (including the status of recurrence and death) of the upper urinary-tract cancer patients? A total of 50 patients with of the upper urinary tract TCC were studied retrospectively at Mackay Memorial Hospital, Taiwan, between 1996 and 2003. Prospective cohort follow-up research design and survival statistical analysis were used in this pilot study. According to survival analysis, C-met had significant influence upon the survival status of all patients (log-rank p=0.0261, Wilcoxon p=0.0166). The combination of tumor markers (grade、FGFR3、p53、C-met、p63) had significant influence both upon the survival status (log-rank p=0.0226, Wilcoxon p=0.0234) and the recurrence/metastasis status (log-rank p=0.0236, Wilcoxon p=0.0257) of all patients. Findings hold important implications for clinical professional, education, and clinical research to improve the health, and then increase the life years of population in Taiwan. The results of this study can be provided for gene-prevention, gene-detection, and gene-therapy related the upper urinary-tract cancer. The result not only can be used in Taiwan, but also can extrapolate to all Chinese who live in the East. Recommendations were discussed for further study.