On-line Assessment of Internal Dose in Nuclear Medicine

• Main Authors: Yuan-Shan Lin, 林源山
• Other Authors: Chuan-Jong Tung
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/24995823736611754389

碩士 === 國立清華大學 === 原子科學系 === 92 === Abstract Internal dose, including absorbed dose, equivalent dose, committed dose and effective dose, is the results of radionuclides in the body. The application of internal dose covers two main areas, namely radiation protection and nuclear medicine. In nuclear medicine, radioactive pharmaceuticals enter the body through injection and oral intake. Internal dosimetry is an uneasy task in nuclear medicine due to the variation of biokinetics in individual patients despite of the short half-life of radiopharmaceuticals and known physical and chemical characteristics. The present study is to establish a model of medical internal dosimetry by the MIRD (Medical Internal Radiation Dosimetry) calculation techniques and provide the standard reference for quality assurance of medical radiation dosimetry. This study was applied to the Siemens ECAM+ dual head gamma camera using NucliDose on-line assessment program. NucliDose has been installed to estimate the absorbed dose in the nuclear medicine imaging. Further, thermoluminescent dosimeters (TLDs) have been used to measure the absorbed doses to nuclear medicine patients (phantoms). Results of NucliDose on-line assessment and TLD measurement are compared to each other. After corrections, the estimated results of NucliDose are larger than the measured results of TLD. In the target organ, two results are very close. On the other hand, in the source organ, NucliDose is about 3 times larger than TLD, but this two results are in the order of magnitude. The most difficult reason to assess the internal dosimetry is the differences between people. NucliDose collocated with nuclear imaging system is a powerful tool for us to know how the differences are. And during the study, we establish a procedure to assess the internal dosimetry. This procedure is able to provide the professional to do their future study.