| Summary: | 碩士 === 國立臺灣師範大學 === 人類發展與家庭研究所 === 92 === Recent evidence from Women’s Health Initiative (WHI) clinical trails show increased risks of breast cancer, coronary heart disease, stroke and pulmonary embolism in women receiving traditional hormone (combined estrogen/progestin) replacement therapy. Interest in the use of phytoestrogen in place of traditional HRT has increased tremendously. This study is designed to investigate the influences of yam plus adley on sex hormone, blood lipids and antioxidant status in postmenopausal women.
A randomized, single-blind, placebo-controlled, cross-over,trial was conducted on twenty-nine apparently healthy postmenopausal women without HRT recruited from the area of National Taiwan Normal University. After 2-wk run-in period, 15 subjects took 50 g of yam powder plus 50 g of adley powder per day and the others took rice powder as a placebo for 5 weeks and then the order was switched vice versa to continue for another 5 weeks with 3-week washout period. Subjects maintained their usual diet and physical activity throughout the intervention and took their powder from the laboratory every week. Blood and first morning urine samples were collected in the beginning and the end of each period for the measurements of blood sugar, blood lipids, antioxidant capacity (the susceptibility of LDL to oxidation, TBARS level) and sex hormones (serum Estrone, Estradiol, SHBG, DHEAS, FSH). Twenty-three subjects completed the study.
The results showed that body fat increased significantly after both supplements and the increase was significantly greater in yam plus adley than in placebo. the levels of blood sugar, plasma cholesterol and plasma HDL2-Cdecreased (p=0.014, p=0.073, p=0.042, respectively) after yam plus adley .Since the decrease in HDL2-C did not resulted in an increase in LDL-C/HDL-C, it appears not to have deleterious effect. TBARS production of oxidized LDL decreased significantly after yam plus adley supplementation. There was no significant difference in sex hormones except in FSH where the decrease after yam + adley was significant as compared with that after placebo. The results show that the ingestion of yam and adley might be beneficial in decreasing plasma glucose and LDL oxidation.
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