Effects of cholesterol supplementation on lipid metabolism in hamsters.
碩士 === 國立臺灣海洋大學 === 食品科學系 === 92 === Abstract The study was designed to investigate the effect of different cholesterol supplementation on lipid metabolism in male Syrian hamsters. The hamsters were divided into five group:(1) control group ( 0% cholesterol supplementation ) (2) 0.1CH group ( 0....
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ndltd-TW-092NTOU52530262016-06-01T04:21:56Z http://ndltd.ncl.edu.tw/handle/91081141771123043478 Effects of cholesterol supplementation on lipid metabolism in hamsters. 不同膽固醇添加量對倉鼠脂質代謝之影響 Hung-Sheng Hsu 許弘昇 碩士 國立臺灣海洋大學 食品科學系 92 Abstract The study was designed to investigate the effect of different cholesterol supplementation on lipid metabolism in male Syrian hamsters. The hamsters were divided into five group:(1) control group ( 0% cholesterol supplementation ) (2) 0.1CH group ( 0.1% cholesterol supplementation ) (3) 0.2CH group ( 0.2% cholesterol supplementation ) (4) 0.5CH group ( 0.5 % cholesterol supplementation ) (5) 1CH group ( 1% cholesterol supplementation ). The results showed that cholesterol supplementation significantly increased liver weight in hamsters. In addition, plasma total cholesterol and plasma high density lipoprotein cholesterol ( HDL-C )、very low density lipoprotein cholesterol ( VLDL-C )、low density lipoprotein ( LDL-C ) concentration in hamsters significantly increased and the ratios of HDL-C to LDL-C significant decreased with cholesterol supplementation. Althogh cholesterol supplementation significanty increased fecal cholesterol contents, no significant change in fecal total bile acids excretion was observed. On the other hand, hamsters fed a diet with high cholesterol supplementation had higher plasma ALT( Alanine transaminase ) activities and lower hepatic TBARS values. The insulin and leptin levels in plasma was significantly decreased but the CETP (cholesteryl ester transfer protein ) levels in plasma was increased. after cholesterol supplementationt in hamsters. Results from the present standy suggest that cholesterol supplementation may increase plasma total, LDL, VLDL cholesterol concentrations and induce hepatic cholesterol accumulation, and 0.43% dietary cholesterol supplementation may cause the highest VLDL cholesterol concentration and hepatic cholesterol accumulation. Key words: cholesterol, lipid metabolism, hamsters Meng-Tsan Chiang 江孟燦 2004 學位論文 ; thesis 95 zh-TW |
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碩士 === 國立臺灣海洋大學 === 食品科學系 === 92 === Abstract
The study was designed to investigate the effect of different cholesterol supplementation on lipid metabolism in male Syrian hamsters. The hamsters were divided into five group:(1) control group ( 0% cholesterol supplementation ) (2) 0.1CH group ( 0.1% cholesterol supplementation ) (3) 0.2CH group ( 0.2% cholesterol supplementation ) (4) 0.5CH group ( 0.5 % cholesterol supplementation ) (5) 1CH group ( 1% cholesterol supplementation ). The results showed that cholesterol supplementation significantly increased liver weight in hamsters. In addition, plasma total cholesterol and plasma high density lipoprotein cholesterol ( HDL-C )、very low density lipoprotein cholesterol ( VLDL-C )、low density lipoprotein ( LDL-C ) concentration in hamsters significantly increased and the ratios of HDL-C to LDL-C significant decreased with cholesterol supplementation. Althogh cholesterol supplementation significanty increased fecal cholesterol contents, no significant change in fecal total bile acids excretion was observed. On the other hand, hamsters fed a diet with high cholesterol supplementation had higher plasma ALT( Alanine transaminase ) activities and lower hepatic TBARS values. The insulin and leptin levels in plasma was significantly decreased but the CETP (cholesteryl ester transfer protein ) levels in plasma was increased. after cholesterol supplementationt in hamsters. Results from the present standy suggest that cholesterol supplementation may increase plasma total, LDL, VLDL cholesterol concentrations and induce hepatic cholesterol accumulation, and 0.43% dietary cholesterol supplementation may cause the highest VLDL cholesterol concentration and hepatic cholesterol accumulation.
Key words: cholesterol, lipid metabolism, hamsters
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author2 |
Meng-Tsan Chiang |
author_facet |
Meng-Tsan Chiang Hung-Sheng Hsu 許弘昇 |
author |
Hung-Sheng Hsu 許弘昇 |
spellingShingle |
Hung-Sheng Hsu 許弘昇 Effects of cholesterol supplementation on lipid metabolism in hamsters. |
author_sort |
Hung-Sheng Hsu |
title |
Effects of cholesterol supplementation on lipid metabolism in hamsters. |
title_short |
Effects of cholesterol supplementation on lipid metabolism in hamsters. |
title_full |
Effects of cholesterol supplementation on lipid metabolism in hamsters. |
title_fullStr |
Effects of cholesterol supplementation on lipid metabolism in hamsters. |
title_full_unstemmed |
Effects of cholesterol supplementation on lipid metabolism in hamsters. |
title_sort |
effects of cholesterol supplementation on lipid metabolism in hamsters. |
publishDate |
2004 |
url |
http://ndltd.ncl.edu.tw/handle/91081141771123043478 |
work_keys_str_mv |
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