Effects of cholesterol supplementation on lipid metabolism in hamsters.

• Main Authors: Hung-Sheng Hsu, 許弘昇
• Other Authors: Meng-Tsan Chiang
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/91081141771123043478

碩士 === 國立臺灣海洋大學 === 食品科學系 === 92 === Abstract The study was designed to investigate the effect of different cholesterol supplementation on lipid metabolism in male Syrian hamsters. The hamsters were divided into five group：(1) control group ( 0％ cholesterol supplementation ) (2) 0.1CH group ( 0.1％ cholesterol supplementation ) (3) 0.2CH group ( 0.2％ cholesterol supplementation ) (4) 0.5CH group ( 0.5 ％ cholesterol supplementation ) (5) 1CH group ( 1％ cholesterol supplementation ). The results showed that cholesterol supplementation significantly increased liver weight in hamsters. In addition, plasma total cholesterol and plasma high density lipoprotein cholesterol ( HDL-C )、very low density lipoprotein cholesterol ( VLDL-C )、low density lipoprotein ( LDL-C ) concentration in hamsters significantly increased and the ratios of HDL-C to LDL-C significant decreased with cholesterol supplementation. Althogh cholesterol supplementation significanty increased fecal cholesterol contents, no significant change in fecal total bile acids excretion was observed. On the other hand, hamsters fed a diet with high cholesterol supplementation had higher plasma ALT( Alanine transaminase ) activities and lower hepatic TBARS values. The insulin and leptin levels in plasma was significantly decreased but the CETP (cholesteryl ester transfer protein ) levels in plasma was increased. after cholesterol supplementationt in hamsters. Results from the present standy suggest that cholesterol supplementation may increase plasma total, LDL, VLDL cholesterol concentrations and induce hepatic cholesterol accumulation, and 0.43％ dietary cholesterol supplementation may cause the highest VLDL cholesterol concentration and hepatic cholesterol accumulation. Key words: cholesterol, lipid metabolism, hamsters