| Summary: | 博士 === 國立臺灣大學 === 電機工程學研究所 === 92 === The top ten mortality causes in twenty-one century, nearly all lead to systemic multi-organ disorder or failure in the last stage. In the point view of medical engineering, system failure is the general mechanism and ending of these causes.
Thought the quantitatively physiological analysis and medical device design, medical engineering utilizes systemic thinking and engineer knowledge to solve the clinical problems；therefore, we designed animal and clinic experiments to evaluate the coefficient of harmonic variation of magnitude (HCVs) and found that all the harmonic components gradually lost their stability during dying process. The HCVs, which increased first for the high-frequency components and then the low-frequency components, could quantitatively reflect the process of system failure. Meanwhile, through the design and evaluation of a noninvasive device, we proved the HCVs’ ability applied to the new medical device development.
The HCVs，which systematically and quantitatively indicates the severity of different stages of illness and dying process，confirms the Chinese medical system established from pulse diagnosis and provides the fundamental to the integration of medicine；moreover, could indicate a new way to cure the top ten mortality diseases in our time.
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