| Summary: | 碩士 === 國立臺灣大學 === 獸醫學研究所 === 92 === Abstract
Heart failure (HF) is a common clinical syndrome presented in canine patients. Understanding of blood pressure (BP) distribution in HF dogs may help clinicians manage this complex hemodynamic disorder. In veterinary literatures, however, there was only limited information about BP reference value or judgment criteria in canine HF patients. The purposes of present study were to survey BP distribution in canine HF patients according to different treatment and disease conditions under clinical situations, to investigate association between management of HF and BP expression, and to clarify the role of BP in canine HF cases. Two hundreds and twenty-seven dogs affected with HF were studied. Systolic blood pressure values of these dogs were measured by an ultrasonic Doppler flow detector. The range and variation of the BP distribution in unstable HF dogs (157.7 ± 43.4 mmHg) were considerably larger than in stable HF dogs (151.6 ± 14.7 mmHg), and there was a significant difference between variances in two groups (p<0.001). Breed, sex, age and concurrent renal disease or endocrine problems did not affect BP distributions of HF dogs. However, in unstable HF group, BP values decreased significantly with increase of HF class (p=0.03), and are significantly higher in obese HF dogs (p=0.006). Among these 227 in the present study, 61 dogs were able to receive medication regularly and became clinically stable. The pre- and post-stable BP of these 61 dogs was 160.0 ± 47.6 mmHg and 152.4 ± 15.0 mmHg respectively. After clinical stabilization, the dispersion of BP distribution expressed by standard deviation decreased, and BP values rose or fell into a limited range significantly (p<0.001). These 61 cases were then further categorized into normal-high BP (n=44) and low BP (n=17) subgroup based upon their pre-stable BP. Blood pressure of both subgroups exhibited statistically significant difference (p=0.001 & p<0.001) before and after clinical stabilization. In both subgroups, there were no differences in improvement of HF class and clinically improved time. But dogs in low BP subgroup needed shorter time to reach clinically stabilization. Based upon our results, the target range of systolic BP for management of canine HF should be set at 133.2 ~ 171.6 mmHg. In conclusion, blood pressure had a tendency to become stable after clinically stabilization of canine HF patients. Application of BP measurement might be of clinical importance in managing canine HF cases.
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