Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model
碩士 === 國立臺灣大學 === 電機工程學研究所 === 92 === An optimized treatment plan procedure of radiation therapy (RT) is done by delivering a sufficient dose of radiation to eradicate cancerous cells without having severe complication in healthy organs. For this reason, radiobiological models should be introduced t...
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ndltd-TW-092NTU054420572016-06-10T04:15:57Z http://ndltd.ncl.edu.tw/handle/86299079364054085619 Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model 利用平行性器官生物機率模型分析正常肝細胞因放射線照射產生併發症機率大小之研究 Hua-Shan Liu 劉華姍 碩士 國立臺灣大學 電機工程學研究所 92 An optimized treatment plan procedure of radiation therapy (RT) is done by delivering a sufficient dose of radiation to eradicate cancerous cells without having severe complication in healthy organs. For this reason, radiobiological models should be introduced to quantify the radiobiological response of normal tissues to radiotherapy. To predict the incidence of radiation-induced disease in parallel organs, the parallel architecture normal tissue complication probability (NTCP) model hypothesizes that a complication would be caused if the damaged fraction of the organ volume (f) exceeds the threshold of a critical one, ft (the “ functional reserve”). This study analyzed data of normal liver function from 4 patient subgroups with the parallel NTCP model to investigate the tolerance of the partial liver irradiation by evaluating the value of f. The calculated f from maximum likelihood estimated (MLE) parameters shows that cases of radiation-induced liver disease (RILD) have been reported in patients with a value of f larger than 0.4. Hsiao-Wen Chung 鍾孝文 2004 學位論文 ; thesis 75 zh-TW |
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碩士 === 國立臺灣大學 === 電機工程學研究所 === 92 === An optimized treatment plan procedure of radiation therapy (RT) is done by delivering a sufficient dose of radiation to eradicate cancerous cells without having severe complication in healthy organs. For this reason, radiobiological models should be introduced to quantify the radiobiological response of normal tissues to radiotherapy. To predict the incidence of radiation-induced disease in parallel organs, the parallel architecture normal tissue complication probability (NTCP) model hypothesizes that a complication would be caused if the damaged fraction of the organ volume (f) exceeds the threshold of a critical one, ft (the “ functional reserve”). This study analyzed data of normal liver function from 4 patient subgroups with the parallel NTCP model to investigate the tolerance of the partial liver irradiation by evaluating the value of f. The calculated f from maximum likelihood estimated (MLE) parameters shows that cases of radiation-induced liver disease (RILD) have been reported in patients with a value of f larger than 0.4.
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Hsiao-Wen Chung |
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Hsiao-Wen Chung Hua-Shan Liu 劉華姍 |
author |
Hua-Shan Liu 劉華姍 |
spellingShingle |
Hua-Shan Liu 劉華姍 Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
author_sort |
Hua-Shan Liu |
title |
Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
title_short |
Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
title_full |
Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
title_fullStr |
Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
title_full_unstemmed |
Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model |
title_sort |
analysis of radiation-induced liver disease using the parallel architecture ntcp model |
publishDate |
2004 |
url |
http://ndltd.ncl.edu.tw/handle/86299079364054085619 |
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