Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator
碩士 === 國立臺灣大學 === 醫學工程學研究所 === 92 === To probe into the mystery of human brain, we are motivated to study the somatosensory system. Among various sensory modalities, the pain sensation plays an important role in any species. How to release “pain,” especially for a patient with cancer diseases is an...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Published: |
2004
|
Online Access: | http://ndltd.ncl.edu.tw/handle/98637750166713010345 |
id |
ndltd-TW-092NTU05530002 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-092NTU055300022016-06-10T04:15:41Z http://ndltd.ncl.edu.tw/handle/98637750166713010345 Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator 二氧化碳雷射在大鼠尾部進行傷害性刺激之大腦皮質反應的分析及機械式傷害性刺激器之開發 Wen-Li Liao 廖文琍 碩士 國立臺灣大學 醫學工程學研究所 92 To probe into the mystery of human brain, we are motivated to study the somatosensory system. Among various sensory modalities, the pain sensation plays an important role in any species. How to release “pain,” especially for a patient with cancer diseases is an important issue in clinical practice. It is however due partially to the show, conduction velocity of pain sensation and the localization in the CNS is not clear; studies on pain have hardly break–through findings. In this investigation, we used CO2 laser as noxious stimulation to induce “pain” in the tail of the rat. The evoked potential was recorded within the rat’s cerebral cortex and analyzed with current-source-density in turn. We found that the closer the recording distance, with respect to the stimulus the shorter the latency of the evoked responses. The maximally evoked responses were at a deeper layer of the cortex, while compared with those obtained from mechanical stimulation. The responsive center located at 0.9 mm in depth from the surface of the cerebral cortex, and a dipole only could be used to model it. To compare the cortical noxious responses evoked from different sources of energy, a noxious mechanical stimulator was developed in this thesis. This device can quantify the force we applied to the body of the experimental animals, and provide an external synchronous output to trigger the data acquisition system. Furthermore, the applied force is also provided as an output connector in analog form for quatilization purpose. This stimulator could be valuable for further studies in our laboratory. Fu-San Jaw 趙福杉 2004 學位論文 ; thesis 37 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
碩士 === 國立臺灣大學 === 醫學工程學研究所 === 92 === To probe into the mystery of human brain, we are motivated to study the somatosensory system. Among various sensory modalities, the pain sensation plays an important role in any species. How to release “pain,” especially for a patient with cancer diseases is an important issue in clinical practice. It is however due partially to the show, conduction velocity of pain sensation and the localization in the CNS is not clear; studies on pain have hardly break–through findings.
In this investigation, we used CO2 laser as noxious stimulation to induce “pain” in the tail of the rat. The evoked potential was recorded within the rat’s cerebral cortex and analyzed with current-source-density in turn. We found that the closer the recording distance, with respect to the stimulus the shorter the latency of the evoked responses. The maximally evoked responses were at a deeper layer of the cortex, while compared with those obtained from mechanical stimulation. The responsive center located at 0.9 mm in depth from the surface of the cerebral cortex, and a dipole only could be used to model it.
To compare the cortical noxious responses evoked from different sources of energy, a noxious mechanical stimulator was developed in this thesis. This device can quantify the force we applied to the body of the experimental animals, and provide an external synchronous output to trigger the data acquisition system. Furthermore, the applied force is also provided as an output connector in analog form for quatilization purpose. This stimulator could be valuable for further studies in our laboratory.
|
author2 |
Fu-San Jaw |
author_facet |
Fu-San Jaw Wen-Li Liao 廖文琍 |
author |
Wen-Li Liao 廖文琍 |
spellingShingle |
Wen-Li Liao 廖文琍 Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
author_sort |
Wen-Li Liao |
title |
Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
title_short |
Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
title_full |
Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
title_fullStr |
Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
title_full_unstemmed |
Analysis of cortical noxious responses caused by CO2 laser stimulation in the tail of the rat and Development of a mechanical noxious stimulator |
title_sort |
analysis of cortical noxious responses caused by co2 laser stimulation in the tail of the rat and development of a mechanical noxious stimulator |
publishDate |
2004 |
url |
http://ndltd.ncl.edu.tw/handle/98637750166713010345 |
work_keys_str_mv |
AT wenliliao analysisofcorticalnoxiousresponsescausedbyco2laserstimulationinthetailoftheratanddevelopmentofamechanicalnoxiousstimulator AT liàowénlí analysisofcorticalnoxiousresponsescausedbyco2laserstimulationinthetailoftheratanddevelopmentofamechanicalnoxiousstimulator AT wenliliao èryǎnghuàtànléishèzàidàshǔwěibùjìnxíngshānghàixìngcìjīzhīdànǎopízhìfǎnyīngdefēnxījíjīxièshìshānghàixìngcìjīqìzhīkāifā AT liàowénlí èryǎnghuàtànléishèzàidàshǔwěibùjìnxíngshānghàixìngcìjīzhīdànǎopízhìfǎnyīngdefēnxījíjīxièshìshānghàixìngcìjīqìzhīkāifā |
_version_ |
1718300088940363776 |