Time to Pregnancy Study in Male Workers Exposed to Carbon Disulfide in the Rayon Industry;Reproductive Endocrine Study in Male Workers Exposed to Carbon Disulfide in the Rayon Industry

• Main Authors: Kuang-Yi Chang, 張光億
• Other Authors: 陳保中
• Format: Others
• Language: en_US
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/06718700085312529071

碩士 === 國立臺灣大學 === 職業醫學與工業衛生研究所 === 92 === part I The aim of study was to estimate whether exposed to carbon disulfide (CS2) has an impact on couple fecundability. For couple fecundability used a retrospective cohort in design. A total of 56 male workers in the rayon industry were recruited. We used time to pregnancy (TTP) as a measure of couple fecundability, which was defined as the duration between the dates of discontinuing contraceptive procedures and beginning of last menstrual period before pregnancy, and used a structured questionnaire to interview each male worker and his spouse. We conducted the exposure assessment of CS2 using previously air-sampling data. Finally, we analyzed the data of TTP using the discrete Cox’s proportional hazards model. The pregnancies with the employment of 10 years or more had a lower fecundability density ratio (FDR＝0.47; 95% CI: 0.23 to 0.93) and those exposed more than 30 ppm had a lower ratio (FDR＝0.58; 95% CI: 0.26 to 1.29) compared to those before the employment. Furthermore, workers exposed more than 30 ppm and their employment of 10 years or more were associated with a decreased fecundability density ratio (FDR＝0.42; 95% CI: 0.19 to 0.93). The results showed that the exposure to CS2 had a significant effect on male fecundability, especially for those with the CS2 exposure of long duration and high concentration. part II The objective of the study was to estimate whether exposed to carbon disulfide (CS2) has an impact on male reproductive endocrine. The study was a cross-sectional study in design. The study population consisted of 53 male workers with the continuous work in the rayon manufacturing factory at least three months. All 53 workers from the department of a viscose rayon factory with potentially direct exposure to CS2, and 106 male workers in other factories were recruited as the exposed groups and non-exposed group. We conducted the exposure assessment of CS2 using previously air-sampling data, including area and personal sampling. We calculated not only cumulative potential exposure dose from information on the total number of years working with CS2 but also cumulative index (ppm×years). The level of serum follicle stimulating hormone (FSH), luetinizing hormone (LH), total testosterone, and inhibin B were used to determine by enzyme-linked immunosorbent assay (ELISA). Finally, we analyzed the data of reproductive endocrine using the General linear models. The exposure group of serum FSH, LH, and testosterone were no significant association with exposure after age stratified. However, the serum inhibin B was significantly increased with high exposure. We found the potential effects of exposure CS2 induced subclinical alterations in male reproductive endocrine. Furthermore, the CS2 damage on reproductive endocrine mechanism is still a question that we need to clarify.