Preparation the Synthons of Fluorine-containing Phosphonates

碩士 === 國防大學中正理工學院 === 應用化學研究所 === 93 === Treatment of triethylphosphite ((EtO)3P) with dibromodifluoromethane (CF2Br2) in diethyl ether at room temperature afforded diethyl(bromodifluor- omethyl)phosphonate ((EtO)2P(O)CF2Br) in good yield. Subsequent reaction of (EtO)2P(O)CF2Br with activated zinc i...

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Main Authors:	Ching-Wei Fang, 方京維
Other Authors:	Hou-Jen Tsai
Format:	Others
Language:	zh-TW
Published:	2005
Online Access:	http://ndltd.ncl.edu.tw/handle/97559623546869874398

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spelling	ndltd-TW-093CCIT05000112015-10-13T12:56:39Z http://ndltd.ncl.edu.tw/handle/97559623546869874398 Preparation the Synthons of Fluorine-containing Phosphonates 有機磷氟化學在化學戰劑上的應用 Ching-Wei Fang 方京維碩士國防大學中正理工學院應用化學研究所 93 Treatment of triethylphosphite ((EtO)3P) with dibromodifluoromethane (CF2Br2) in diethyl ether at room temperature afforded diethyl(bromodifluor- omethyl)phosphonate ((EtO)2P(O)CF2Br) in good yield. Subsequent reaction of (EtO)2P(O)CF2Br with activated zinc in monoglyme gave [(diethoxyphosphinyl)- difluoromethyl]zinc bromide (EtO)2P(O)CF2ZnBr. Acylation of (EtO)2P(O)CF2ZnBr with strong electrophiles such as ethyloxalyl chloride (ClC(O)CO2Et), ethyl chloroformate (ClC(O)OEt) and diethylcarbamoyl chloride (ClC(O)NEt2) gave only diethyl 2-oxo-1,1-difluorophosphonates (EtO)2P(O)CF2C(O)CO2Et. No products of (EtO)2P(O)CF2C(O)OEt and (EtO)2P(O)CF2C(O)NEt2 were observed. Hou-Jen Tsai 蔡厚仁 2005 學位論文 ; thesis 79 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國防大學中正理工學院 === 應用化學研究所 === 93 === Treatment of triethylphosphite ((EtO)3P) with dibromodifluoromethane (CF2Br2) in diethyl ether at room temperature afforded diethyl(bromodifluor- omethyl)phosphonate ((EtO)2P(O)CF2Br) in good yield. Subsequent reaction of (EtO)2P(O)CF2Br with activated zinc in monoglyme gave [(diethoxyphosphinyl)- difluoromethyl]zinc bromide (EtO)2P(O)CF2ZnBr. Acylation of (EtO)2P(O)CF2ZnBr with strong electrophiles such as ethyloxalyl chloride (ClC(O)CO2Et), ethyl chloroformate (ClC(O)OEt) and diethylcarbamoyl chloride (ClC(O)NEt2) gave only diethyl 2-oxo-1,1-difluorophosphonates (EtO)2P(O)CF2C(O)CO2Et. No products of (EtO)2P(O)CF2C(O)OEt and (EtO)2P(O)CF2C(O)NEt2 were observed.
author2	Hou-Jen Tsai
author_facet	Hou-Jen Tsai Ching-Wei Fang 方京維
author	Ching-Wei Fang 方京維
spellingShingle	Ching-Wei Fang 方京維 Preparation the Synthons of Fluorine-containing Phosphonates
author_sort	Ching-Wei Fang
title	Preparation the Synthons of Fluorine-containing Phosphonates
title_short	Preparation the Synthons of Fluorine-containing Phosphonates
title_full	Preparation the Synthons of Fluorine-containing Phosphonates
title_fullStr	Preparation the Synthons of Fluorine-containing Phosphonates
title_full_unstemmed	Preparation the Synthons of Fluorine-containing Phosphonates
title_sort	preparation the synthons of fluorine-containing phosphonates
publishDate	2005
url	http://ndltd.ncl.edu.tw/handle/97559623546869874398
work_keys_str_mv	AT chingweifang preparationthesynthonsoffluorinecontainingphosphonates AT fāngjīngwéi preparationthesynthonsoffluorinecontainingphosphonates AT chingweifang yǒujīlínfúhuàxuézàihuàxuézhànjìshàngdeyīngyòng AT fāngjīngwéi yǒujīlínfúhuàxuézàihuàxuézhànjìshàngdeyīngyòng
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Preparation the Synthons of Fluorine-containing Phosphonates

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