Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies
碩士 === 長庚大學 === 醫學生物技術研究所 === 93 === Colon cancer has been listed as the third cause of death among cancers in Taiwan. However, the lack of an effective early detection screening methods is the major barrier to improve the treatment of patients with colon cancer. According to recent studies, some tu...
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ndltd-TW-093CGU006040132015-10-13T15:29:17Z http://ndltd.ncl.edu.tw/handle/00179742206173405886 Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies 大腸癌及鼻咽癌體外檢驗試劑套組之研發 Yu-Han chen 陳鈺翰 碩士 長庚大學 醫學生物技術研究所 93 Colon cancer has been listed as the third cause of death among cancers in Taiwan. However, the lack of an effective early detection screening methods is the major barrier to improve the treatment of patients with colon cancer. According to recent studies, some tumor-associated antigens can specifically recognize cancer patient’s autologous antibodies. Therefore, we used nine colon cancer antigens to detect specific antibodies in patient’s serum. Antibody reactivity against these antigens were determined in sera with from patients with colon cancer (n=105) and healthy donors (n=54). The five antigens which are named NY-CO-8, NY-CO-9, NY-CO-13, NY-CO-16 and NY-CO-20 got better reactivities, and sensitivity of these antigens was in the range of 17.1%- 36.8%. The combined analysis of the panel of the antibody reactivities, the sensitivity is 61.0 %, the specificity is 92.6 %. The addition analysis of CEA value could increase the sensitivity to 70.1% and, 43.5 % of the patients at early stages are detected. The ELISA format is cost-effective and feasible for mass screening; the specific panel of these profiles may be worth for early detection. 詹爾昌 2005 學位論文 ; thesis 0 zh-TW |
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碩士 === 長庚大學 === 醫學生物技術研究所 === 93 === Colon cancer has been listed as the third cause of death among cancers in Taiwan. However, the lack of an effective early detection screening methods is the major barrier to improve the treatment of patients with colon cancer. According to recent studies, some tumor-associated antigens can specifically recognize cancer patient’s autologous antibodies. Therefore, we used nine colon cancer antigens to detect specific antibodies in patient’s serum. Antibody reactivity against these antigens were determined in sera with from patients with colon cancer (n=105) and healthy donors (n=54). The five antigens which are named NY-CO-8, NY-CO-9, NY-CO-13, NY-CO-16 and NY-CO-20 got better reactivities, and sensitivity of these antigens was in the range of 17.1%- 36.8%. The combined analysis of the panel of the antibody reactivities, the sensitivity is 61.0 %, the specificity is 92.6 %. The addition analysis of CEA value could increase the sensitivity to 70.1% and, 43.5 % of the patients at early stages are detected. The ELISA format is cost-effective and feasible for mass screening; the specific panel of these profiles may be worth for early detection.
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author2 |
詹爾昌 |
author_facet |
詹爾昌 Yu-Han chen 陳鈺翰 |
author |
Yu-Han chen 陳鈺翰 |
spellingShingle |
Yu-Han chen 陳鈺翰 Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
author_sort |
Yu-Han chen |
title |
Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
title_short |
Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
title_full |
Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
title_fullStr |
Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
title_full_unstemmed |
Development of in vitro Diagnostic Kits for Colon Cancer and Nasopharyngeal Carcinoma with Specific Panel of Antibodies |
title_sort |
development of in vitro diagnostic kits for colon cancer and nasopharyngeal carcinoma with specific panel of antibodies |
publishDate |
2005 |
url |
http://ndltd.ncl.edu.tw/handle/00179742206173405886 |
work_keys_str_mv |
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