Design and Synthesis of 2-benzothiazoles Derivative as Anticancer Agents and Nonlinear Optical Chromophore

• Main Authors: Yan-Ren Chen, 陳彥任
• Other Authors: Jeh-Jeng Wang
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/17156706608514276417

碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 93 === 2-Benzothiazoles reported that they display potent and selective anti-tumor activity against inter alia breast, ovarian, colon, and renal cell lines, but their mechanism of action, through yet to be defined, may be novel. Metabolism is suspected to play a central role in the mode of action cell lines. We designed and synthesized different subtituents at aromatic positions of 2-benzothiazolesfor biological test. Beside the anti-tumor agents, the similar structures are also the novel start in the optical materials. More than change the different electron donor and accepter, we use the tri-fluoromethyl in the chromophores as the electron accepter, and the amine or hydroxyl group as the electron donor, the tri-fluoromethyl group not only be a electron accepter but also improve is solubility. The new idea maybe can solve the problem of low solubility.