Stable Chemical Modifications of PDMS Surfaces for Microchip Application

• Main Authors: Ya-Yu Hsieh, 謝雅玉
• Other Authors: Shu-Hui Chen
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/82985508166621534202

碩士 === 國立成功大學 === 化學系專班 === 93 === This study aims to dig out a solution of PDMS microchip has an extreme hydrophobic surface in order to obtain a permanent hydrophilic surface and resistance to protein absorption, which can be made by inducing utilize the various polymers for chemical modification in the PDMS microchip. Otherwise, through contact angle measure the hydrophilic property and use Attenuated Total Reflectance Fourier Infrared Spectroscopy (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA) to analyze the functional group and the elementary analysis of PDMS surface modified with thin film, and furthermore, to monitor the stability of the thin film during a period. In other hand we used Atomic Force Microscopy (AFM) observed the morphology of the modified layer.We also used EOF measurement to demonstrate the reproduction of surface charge of micro-channel on the modified PDMS. Therefore, the stable, hydrophilic, protein-resistant thin film coatings will be very useful for commercial PDMS microfluidic chips, which require long-term stability and for protein-resistant PDMS biomaterials.