The application of tissue engineering in autotransplantation of tooth

• Main Authors: Fang,Chin-Yuang, 方致元
• Other Authors: Chen,Jenn-han
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/80712721286433676787

碩士 === 國防醫學院 === 牙醫科學研究所 === 93 === Dental implant and autotransplantation of tooth are the only two practical ways to increase the number of abutment tooth over the edentulous region. High successful rate and friendly technical procedures are the well known advantage of dental implant. However, high price and long healing period are its major problems. Comparing to dental implant, autotransplantaion is cheaper and has shorter healing period (about 3 weeks), there are still many clinical limitations of autotransplantation. Besides, high technical sensitivity is the another problem of it. In order to overcome the limitation of autotransplantation, the concept of tissue engineering has been proposed. In this study, we developed a transplanted the single-root-teeth of beagle dog translaterally as the animal model. The enamel matrix derivative (Emdogain®) was applied onto the root surface and the recipient socket before the teeth were transplanted. Consequently, the junction of the tooth and socket were covered with the biodegradable membrane (Atrisorb®). No special treatment had been done in the control group. After 4 and 8 weeks, the dogs were sacrificed. The teeth and their surrounding periodontal tissues were prepared for histological observation. All teeth were clinical success after transplantation by showing normal mobility, no periodontal pocket and no metallic sound. Root resorption, however, was noted in every root from both control and test group under microscope examination. The control group was obviously more serious. Comparing between the control and test group, the benefit of application of tissue engineering are summarized as following: (1) less root resorption, (2) increased the rate of healing process and production of PDL, (3)increased the rate of remodeling of cementum and alveolar bone,(4) Sharpey’s fibers formation noted in the most root surface in test group, (5)increase new attachment formation and (6)more bone support