reduction in the presence of O-protected α-hydroxy carbonic acid esters and β-hydroxy carbonic acid esters of sodium hydride
碩士 === 國立高雄師範大學 === 化學系 === 93 === Chrial dialcohols，especially chiral dialcohols having protected chiral center [1,2]， are frequently used as precusor in synthesis of natural products。Such chiral dialcohols are prepared by the reduction of α-hydroxy carboxylic acid esters in the presence of LiAlH4...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2005
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| Online Access: | http://ndltd.ncl.edu.tw/handle/71815149167446226458 |
| Summary: | 碩士 === 國立高雄師範大學 === 化學系 === 93 === Chrial dialcohols，especially chiral dialcohols having protected chiral center [1,2]， are frequently used as precusor in synthesis of natural products。Such chiral dialcohols are prepared by the reduction of α-hydroxy carboxylic acid esters in the presence of LiAlH4 [3~12]。We have used the specific chiral alcohols as terminal groups for the preparation of chiral liquid crystals。These specific alcohols are synthesized by the reduction of the corresponding chiral esters derived from natural ethyl lactate in the presence of NaBH4 。The yields are good。In order to study the relationship between structure and reductivity deeply。The hydroxy group of ethyl lactate and ethyl β-hydroxy butyrate is protected with frequently used protecting groups。Two series of chiral esters are then reduced in the presence of NaBH4。
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