Polymorphism of angiotensin-converting enzyme gene and BMI differences between aborigines and non-aborigines

• Main Authors: Chien-li Chen, 陳建利
• Other Authors: none
• Format: Others
• Language: en_US
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/58622151087186772930

碩士 === 國立中山大學 === 生物科學系研究所 === 93 === The renin–angiotensin system (RAS) plays a role in the pathogenesis of obesity. Angiotensin-converting enzyme (ACE), the component of the RAS system, has recently been found to be completely expressed in human adipose tissue. Angiotensin II, the active component of RAS, may affect adipogenesis and adipocyte metabolism. Among ACE polymorphism, the gene DD genotype has shown to be regulated with a higher agiotensin- converting enzyme level in plasma. Hence, the purpose of this research is to investigate the correlation of ACE gene polymorphism to body mass index (BMI) between aborigines and Han non-aborigines. The relationship of race and ACE insertion (I)/ deletion (D) polymorphism was also analyzed.The results showed a higher value of ACE DD genotype appeared in aborigines (35.7 %) than that in Han population (10.8 %)(p < 0.0001). BMI in aborigines was 26.4±4.6 kg/m2, while in Han population was 24.4±3.6 kg/m2 (P<0.0001). A higher waist circumference value was also found among females aborigines than that found among female in Han population (86.9±10.7 vs 84.3±9.7 cm, P<0.0001). Simple and multiple linear regression analyses showed that both race and ACE gene polymorphism are closely correlated to BMI in all subjects. By discussion on the cases for the Han and aborigines population separately, it was found that the ACE gene polymorphism is associated with BMI in Han population it is not significant in aborigines. In aborigines, life style in culture is associated with BMI. In conclusion, ACE gene polymorphism and race were independent factors correlated to BMI, but differences could be found between race and ACE gene polymorphism.