A Study on Analysis of Hepatitis B Virus Genotype and Sequence Alignment Systems

• Main Authors: Yi-Yun Wu, 吳宜芸
• Other Authors: Koun-Tem Sun
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/60828042601854609900

碩士 === 國立臺南大學 === 資訊教育研究所碩士班 === 93 === Hepatitis B virus (HBV) includes eight genotypes (A to H) which are categorized by the difference between the nucleotide sequences above 8 percent. The HBV genotype may impact the response of antiviral treatment, clinically significant differences and the change of nucleotide sequences. In this study, we proposed an algorithm to identify HBV genotype and nucleotide sequences difference. We used the principle of probe to make a “Probe Design System” and applied dynamic programming to develop an “Analysis System for the HBV Genotype and Sequence Alignment”. The systems are able to identify the genotype. One of the systems can tell the difference between input sequence and genotype sequence. In this research, we design “probe design system” with the character of probe. And we use encoding method, search function and dynamic programming to design “analysis system for the HBV genotype and sequence alignment”. The experiment shows both systems perform well. We can find the specific probe conditions and the sequence difference with the systems mentioned in the above.