Synthesis and Application of FePt Magnetic Nanoparticles

• Main Authors: Pei-Yu Huang, 黃珮瑜
• Other Authors: Chia-Chun Chen
• Format: Others
• Language: en_US
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/32148028525073694851

碩士 === 國立臺灣師範大學 === 化學系 === 93 === With the proceeding of Nanotechnology and biomedicine, there is a tendency towards integrating the material science and biotechnology. We could separate the magnetic materials from the biomolecules by the characteristics of their magnetism. As a result, there are numerous literature published related to synthesis and application of magnetic nanoparticles (MNPs) up-to-now. The thesis demonstrates the organometallic synthesis of FePt MNPs. With the various surfactants and seed-mediated growth methods, we got not only tunable sizes ( about 3 nm ～ 7 nm ) but homogeneity of as-synthesized FePt MNPs. Alternately, FePt MNPs diluting with desirable carrier solvents resulted in assembling themselves onto a solid carbon substrate. We observed the monolayer, submonolayer, multilayer and even nanoring structure in TEM images. Many applications of biomolecular-magnetic particle hybrid conjugates have been reported recently, the cytotoxicity of MNPs however has not yet been investigated. Consequently we tried to modify the FePt MNPs into hydrophilic with carboxylic acid and also investigated the toxicity of FePt MNPs in live cells using the MTT assay. And our work demonstrated that the FePt MNPs did not cause significant cytotoxicity in HeLa cells. Finally, we report on a one-pot chemical synthesis method for generating the FePt magnetic nanoparticles and the CdS quantum dots. We successfully demonstrated the conjugation of the core-shell structure of nanoparticles about 10 nm.