Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process
碩士 === 國立臺灣大學 === 化學工程學研究所 === 93 === Micronization of the antibiotics (Sulfamethoxazole and Sulfaphenazole) and the non-steroidal anti-inflammatory drugs (Acetaminophen and Sulindac) were investigated in this study using the batch and continuous supercritical carbon dioxide anti-solvent (SAS) preci...
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ndltd-TW-093NTU050630732015-10-13T11:12:50Z http://ndltd.ncl.edu.tw/handle/08472011666319017160 Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process 以超臨界反溶劑沉積法進行藥物微粒化之研究 Yun-Ping Chang 張雲評 碩士 國立臺灣大學 化學工程學研究所 93 Micronization of the antibiotics (Sulfamethoxazole and Sulfaphenazole) and the non-steroidal anti-inflammatory drugs (Acetaminophen and Sulindac) were investigated in this study using the batch and continuous supercritical carbon dioxide anti-solvent (SAS) precipitation method. Particles produced by the continuous SAS are smaller than those produced by the batch ones. Crystal structure of sulfamethoxazole analyzed by XRD showed the solid-solid transition after the batch SAS process. The effect of the process parameters were compared using sulfamethoxazole as model drug. In the batch SAS process, using ethyl acetate as solvent at low concentration favors smaller particle formation while in the continuous SAS process, acetone as solvent was suggested and operating at lower solution flow rate and higher concentration favored smaller particle formation. The micronized sulfamethoxazole exhibits a higher dissolution rate and antibacterial performance. The dissolution test demonstrated the use of additives in drug formulation can be avoided when the SAS processed drug is used. Coprecipitation of sulfamethoxazole and hydroxypropylcellulose (HPC) by the continuous SAS process was also investigated. The dissolution rate of sulfamethoxazole was dramatically enhanced after Coprecipitating with HPC. Yang-Ping Chen 陳延平 2005 學位論文 ; thesis 107 zh-TW |
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碩士 === 國立臺灣大學 === 化學工程學研究所 === 93 === Micronization of the antibiotics (Sulfamethoxazole and Sulfaphenazole) and the non-steroidal anti-inflammatory drugs (Acetaminophen and Sulindac) were investigated in this study using the batch and continuous supercritical carbon dioxide anti-solvent (SAS) precipitation method. Particles produced by the continuous SAS are smaller than those produced by the batch ones. Crystal structure of sulfamethoxazole analyzed by XRD showed the solid-solid transition after the batch SAS process.
The effect of the process parameters were compared using sulfamethoxazole as model drug. In the batch SAS process, using ethyl acetate as solvent at low concentration favors smaller particle formation while in the continuous SAS process, acetone as solvent was suggested and operating at lower solution flow rate and higher concentration favored smaller particle formation. The micronized sulfamethoxazole exhibits a higher dissolution rate and antibacterial performance. The dissolution test demonstrated the use of additives in drug formulation can be avoided when the SAS processed drug is used. Coprecipitation of sulfamethoxazole and hydroxypropylcellulose (HPC) by the continuous SAS process was also investigated. The dissolution rate of sulfamethoxazole was dramatically enhanced after Coprecipitating with HPC.
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author2 |
Yang-Ping Chen |
author_facet |
Yang-Ping Chen Yun-Ping Chang 張雲評 |
author |
Yun-Ping Chang 張雲評 |
spellingShingle |
Yun-Ping Chang 張雲評 Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
author_sort |
Yun-Ping Chang |
title |
Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
title_short |
Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
title_full |
Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
title_fullStr |
Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
title_full_unstemmed |
Micronization of Pharmaceutical Compounds Using Supercritical Anti-Solvent Precipitation Process |
title_sort |
micronization of pharmaceutical compounds using supercritical anti-solvent precipitation process |
publishDate |
2005 |
url |
http://ndltd.ncl.edu.tw/handle/08472011666319017160 |
work_keys_str_mv |
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1716839919853240320 |